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The medial habenula and interpeduncular nucleus circuitry is critical in addiction, anxiety, and mood regulation

Journal of neurochemistry, 2017-08, Vol.142 (S2), p.130-143 [Peer Reviewed Journal]

2017 International Society for Neurochemistry ;2017 International Society for Neurochemistry. ;Copyright © 2017 International Society for Neurochemistry ;ISSN: 0022-3042 ;EISSN: 1471-4159 ;DOI: 10.1111/jnc.14008 ;PMID: 28791703

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Title:
The medial habenula and interpeduncular nucleus circuitry is critical in addiction, anxiety, and mood regulation
Author: McLaughlin, Ian ; Dani, John A. ; De Biasi, Mariella
Subjects: Affect - drug effects ; Affect - physiology ; alcohol ; Animals ; Anxiety ; Anxiety - drug therapy ; Anxiety - physiopathology ; Behavior, Addictive - drug therapy ; Behavior, Addictive - physiopathology ; Circuits ; Conduction ; Disorders ; Drug abuse ; Drug addiction ; Drugs ; epithalamus ; Habenula ; Humans ; interpeduncular nucleus ; Interpeduncular Nucleus - drug effects ; Interpeduncular Nucleus - physiopathology ; Mental depression ; Mood ; Nicotinic Agonists - therapeutic use ; Nuclei ; stress ; Substance Withdrawal Syndrome - drug therapy ; Substance Withdrawal Syndrome - physiopathology ; Withdrawal
Is Part Of: Journal of neurochemistry, 2017-08, Vol.142 (S2), p.130-143
Description: Abstinence from chronic use of addictive drugs triggers an aversive withdrawal syndrome that compels relapse and deters abstinence. Many features of this syndrome are common across multiple drugs, involving both affective and physical symptoms. Some of the network signaling underlying withdrawal symptoms overlaps with activity that is associated with aversive mood states, including anxiety and depression. Given these shared features, it is not surprising that a particular circuit, the dorsal diencephalic conduction system, and the medial habenula (MHb) and interpeduncular nucleus (IPN), in particular, have been identified as critical to the emergence of aversive states that arise both as a result and, independently, of drug addiction. As the features of this circuit continue to be characterized, the MHb‐IPN axis is emerging as a viable target for therapeutics to aid in the treatment of addiction to multiple drugs of abuse as well as mood‐associated disorders. This is an article for the special issue XVth International Symposium on Cholinergic Mechanisms. The medial habenula–interpeduncular nucleus pathway unites forebrain limbic with midbrain and hindbrain motivation and reward signaling. The medial habenula receives afferent inputs from a wide variety of forebrain limbic structures, and the interpeduncular nucleus sends efferent projections to a variety of midbrain and hindbrain structures implicated in the neurophysiology underlying addiction and a variety of mood‐related psychiatric conditions. Accordingly, we propose that this pathway is a junction of signaling which regulates both addiction and mood‐related conditions, and may represent a strategic target for the development of therapeutics. This is an article for the special issue XVth International Symposium on Cholinergic Mechanisms.
Publisher: England: Blackwell Publishing Ltd
Language: English
Identifier: ISSN: 0022-3042
EISSN: 1471-4159
DOI: 10.1111/jnc.14008
PMID: 28791703
Source: IngentaConnect
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE

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The medial habenula and interpeduncular nucleus circuitry is critical in addiction, anxiety, and mood regulation

2017 International Society for Neurochemistry ;2017 International Society for Neurochemistry. ;Copyright © 2017 International Society for Neurochemistry ;ISSN: 0022-3042 ;EISSN: 1471-4159 ;DOI: 10.1111/jnc.14008 ;PMID: 28791703

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