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Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

Diabetes (New York, N.Y.), 2012-01, Vol.61 (1), p.187-196 [Peer Reviewed Journal]

2015 INIST-CNRS ;Copyright American Diabetes Association Jan 2012 ;2012 by the American Diabetes Association. 2012 ;ISSN: 0012-1797 ;EISSN: 1939-327X ;DOI: 10.2337/db11-1029 ;PMID: 22124465 ;CODEN: DIAEAZ

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Title:
Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion
Author: GORBOULEV, Valentin ; SCHÜRMANN, Annette ; VEYHL-WICHMANN, Maike ; SRINIVASAN, Aruna ; BALEN, Daniela ; BRELJAK, Davorka ; REXHEPAJ, Rexhep ; PARKER, Helen E ; GRIBBLE, Fiona M ; REIMANN, Frank ; LANG, Florian ; WIESE, Stefan ; VALLON, Volker ; SABOLIC, Ivan ; SENDTNER, Michael ; KOEPSELL, Hermann ; KIPP, Helmut ; JASCHKE, Alexander ; KLESSEN, Dirk ; FRIEDRICH, Alexandra ; SCHERNECK, Stephan ; RIEG, Timo ; CUNARD, Robyn
Subjects: Animals ; Biological and medical sciences ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Glucose - pharmacokinetics ; Glucose - pharmacology ; Glycosuria - metabolism ; Incretins - metabolism ; Insulin-Secreting Cells - drug effects ; Insulin-Secreting Cells - metabolism ; Intestinal Absorption - genetics ; Intestine, Small - metabolism ; Kidney Tubules, Proximal - drug effects ; Kidney Tubules, Proximal - metabolism ; Male ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Oocytes - drug effects ; Oocytes - metabolism ; Pathophysiology ; Sodium-Glucose Transporter 1 - genetics ; Sodium-Glucose Transporter 1 - metabolism ; Sodium-Glucose Transporter 1 - physiology
Is Part Of: Diabetes (New York, N.Y.), 2012-01, Vol.61 (1), p.187-196
Description: To clarify the physiological role of Na(+)-D-glucose cotransporter SGLT1 in small intestine and kidney, Sglt1(-/-) mice were generated and characterized phenotypically. After gavage of d-glucose, small intestinal glucose absorption across the brush-border membrane (BBM) via SGLT1 and GLUT2 were analyzed. Glucose-induced secretion of insulinotropic hormone (GIP) and glucagon-like peptide 1 (GLP-1) in wild-type and Sglt1(-/-) mice were compared. The impact of SGLT1 on renal glucose handling was investigated by micropuncture studies. It was observed that Sglt1(-/-) mice developed a glucose-galactose malabsorption syndrome but thrive normally when fed a glucose-galactose-free diet. In wild-type mice, passage of D-glucose across the intestinal BBM was predominantly mediated by SGLT1, independent the glucose load. High glucose concentrations increased the amounts of SGLT1 and GLUT2 in the BBM, and SGLT1 was required for upregulation of GLUT2. SGLT1 was located in luminal membranes of cells immunopositive for GIP and GLP-1, and Sglt1(-/-) mice exhibited reduced glucose-triggered GIP and GLP-1 levels. In the kidney, SGLT1 reabsorbed ∼3% of the filtered glucose under normoglycemic conditions. The data indicate that SGLT1 is 1) pivotal for intestinal mass absorption of d-glucose, 2) triggers the glucose-induced secretion of GIP and GLP-1, and 3) triggers the upregulation of GLUT2.
Publisher: Alexandria, VA: American Diabetes Association
Language: English
Identifier: ISSN: 0012-1797
EISSN: 1939-327X
DOI: 10.2337/db11-1029
PMID: 22124465
CODEN: DIAEAZ
Source: MEDLINE
PubMed Central
Alma/SFX Local Collection
ProQuest Central

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Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion

2015 INIST-CNRS ;Copyright American Diabetes Association Jan 2012 ;2012 by the American Diabetes Association. 2012 ;ISSN: 0012-1797 ;EISSN: 1939-327X ;DOI: 10.2337/db11-1029 ;PMID: 22124465 ;CODEN: DIAEAZ

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