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Modulation of bone turnover by alfacalcidol and/or alendronate does not prevent glucocorticoid-induced osteoporosis in growing minipigs

Journal of bone and mineral metabolism, 2005-09, Vol.23 (5), p.341-350 [Peer Reviewed Journal]

2005 INIST-CNRS ;Springer-Verlag Tokyo 2005 ;ISSN: 0914-8779 ;EISSN: 1435-5604 ;DOI: 10.1007/s00774-005-0611-x ;PMID: 16133683

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Title:
Modulation of bone turnover by alfacalcidol and/or alendronate does not prevent glucocorticoid-induced osteoporosis in growing minipigs
Author: AKAHOSHI, Shojiro ; SAKAI, Akinori ; ARITA, Shinobu ; IKEDA, Satoshi ; MORISHITA, Yoshiomi ; TSUTSUMI, Hideki ; ITO, Masako ; SHIRAISHI, Ayako ; NAKAMURA, Toshitaka
Subjects: Absorptiometry, Photon - methods ; Adjuvants, Immunologic - pharmacology ; Alendronate - pharmacology ; Animals ; Biological and medical sciences ; Body Weight ; Bone and Bones - drug effects ; Bone and Bones - metabolism ; Bone Density - drug effects ; Bone Regeneration ; Bone Resorption ; Bones ; Bones, joints and connective tissue. Antiinflammatory agents ; Diseases of the osteoarticular system ; Femur - pathology ; Glucocorticoids - metabolism ; Hydroxycholecalciferols - pharmacology ; Lumbar Vertebrae - metabolism ; Medical sciences ; Osteoporosis ; Osteoporosis - metabolism ; Osteoporosis. Osteomalacia. Paget disease ; Pharmacology. Drug treatments ; Prednisolone - pharmacology ; Swine ; Swine, Miniature ; Time Factors ; Tomography ; Tomography, X-Ray Computed - methods
Is Part Of: Journal of bone and mineral metabolism, 2005-09, Vol.23 (5), p.341-350
Description: The study was performed to clarify the effects of active vitamin D (alfacalcidol) and/or alendronate (ALN) on bone tissue turnover in glucocorticoid (GC)-treated growing minipigs. Göttingen minipigs aged 8 months were divided into six groups (n = 5 each): group BC, killed for baseline control; group GC, injected subcutaneously with prednisolone (0.5 mg/kg body weight [BW] per day, 5 days/week for 24 weeks); group VC, treated with vehicle alone; group alf, treated with oral alfacalcidol at 0.1 microm/kg BW per day, 5 days/week; group ALN, treated with alendronate 1 mg/kg BW per day; and group alf* ALN, treated with both alf and ALN as above. Biochemical examinations dual-energy X-ray absorptiometry, micro-computed tomography, peripheral quantitative computed tomography, and histomorphometry were performed. In group GC, all bone chemical markers were lower than in group VC. GC treatment reduced the age-dependent augmentation of bone mass and structure by reducing the bone formation rate (BFR) and activation frequency (Ac.f) relative to VC in lumbar bone and femoral cortex. Trabecular and osteonal wall thickness values did not change by GC. Treatments with alf, ALN, and alf* ALN did not have substantial effects on bone mass or structure. Alf treatment maintained lumbar BFR and Ac.f, while ALN reduced osteoclasts. Femoral cortical Ac.f values were not affected by these treatments. GC caused reduced bone formation, leading to low tissue turnover and imbalance of bone formation and resorption. Modulation of bone tissue turnover by alfacalcidol and/or alendronate failed to maintain the growth-dependent increases in mass and structure in GC-treated young minipigs.
Publisher: Tokyo: Springer
Language: English
Identifier: ISSN: 0914-8779
EISSN: 1435-5604
DOI: 10.1007/s00774-005-0611-x
PMID: 16133683
Source: MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Modulation of bone turnover by alfacalcidol and/or alendronate does not prevent glucocorticoid-induced osteoporosis in growing minipigs

2005 INIST-CNRS ;Springer-Verlag Tokyo 2005 ;ISSN: 0914-8779 ;EISSN: 1435-5604 ;DOI: 10.1007/s00774-005-0611-x ;PMID: 16133683

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