Language:

Antidiabetic and antioxidant effects and phytochemicals of mulberry fruit (Morus alba L.) polyphenol enhanced extract

PloS one, 2013-07, Vol.8 (7), p.e71144 [Peer Reviewed Journal]

COPYRIGHT 2013 Public Library of Science ;2013 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2013 Wang et al 2013 Wang et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0071144 ;PMID: 23936259

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Antidiabetic and antioxidant effects and phytochemicals of mulberry fruit (Morus alba L.) polyphenol enhanced extract
Author: Wang, Yihai ; Xiang, Limin ; Wang, Chunhua ; Tang, Chao ; He, Xiangjiu
Pintus, Gianfranco
Subjects: Acetic acid ; Animals ; Antioxidants ; Antioxidants - chemistry ; Antioxidants - pharmacology ; Biological activity ; Biology ; Blood proteins ; Blood sugar ; Catalase - metabolism ; Chemistry ; Chronic illnesses ; Diabetes mellitus ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - metabolism ; Enzymatic activity ; Enzyme Activation - drug effects ; Enzymes ; Ethyl acetate ; Flavonoids - analysis ; Flavonoids - chemistry ; Fractionation ; Fruit - chemistry ; Fruits ; Glucosidase ; Glutathione Peroxidase - metabolism ; Glycoside Hydrolase Inhibitors ; Hypoglycemic Agents - chemistry ; Hypoglycemic Agents - pharmacology ; Male ; Medicine ; Mice ; Morus - chemistry ; Morus alba ; NMR ; Nuclear magnetic resonance ; Phenolic compounds ; Phenols ; Phenols - analysis ; Phenols - chemistry ; Phytochemicals ; Phytochemicals - chemistry ; Phytochemicals - pharmacology ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Polyphenols ; Polyphenols - chemistry ; Polyphenols - pharmacology ; Scavenging ; Streptozocin ; Streptozocin - adverse effects ; Superoxide ; Superoxide Dismutase - metabolism ; α-Glucosidase
Is Part Of: PloS one, 2013-07, Vol.8 (7), p.e71144
Description: The antidiabetic and antioxidant activities of the ethyl acetate-soluble extract (MFE) of mulberry fruit (Morus alba L.) were investigated. In vitro, MFE showed potent α-glucosidase inhibitory activity and radical-scavenging activities against DPPH and superoxide anion radicals. In vivo, MFE could significantly decrease fasting blood glucose (FBG) and glycosylated serum protein (GSP), and increase antioxidant enzymatic activities (SOD, CAT, GSH-Px) in streptozotocin (STZ)-induced diabetic mice. Bioactivity-guided fractionation of the MFE led to the isolation of 25 phenolic compounds, and their structures were identified on the basis of MS and NMR data. All the 25 compounds were isolated from mulberry fruit for the first time. Also, the α-glucosidase inhibitory activity and antioxidant activity of the phenolics were evaluated. Potent α-glucosidase inhibitory and radical-scavenging activities of these phenolics suggested that they may be partially responsible for the antidiabetic and antioxidant activities of mulberry fruit.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0071144
PMID: 23936259
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Public Library of Science (PLoS)
ProQuest Central
DOAJ Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Antidiabetic and antioxidant effects and phytochemicals of mulberry fruit (Morus alba L.) polyphenol enhanced extract

Searching Remote Databases, Please Wait