Language:

The impact of needle and syringe provision and opiate substitution therapy on the incidence of hepatitis C virus in injecting drug users: pooling of UK evidence

Addiction (Abingdon, England), 2011-11, Vol.106 (11), p.1978-1988 [Peer Reviewed Journal]

2011 The Authors, Addiction © 2011 Society for the Study of Addiction ;2015 INIST-CNRS ;2011 The Authors, Addiction © 2011 Society for the Study of Addiction. ;ISSN: 0965-2140 ;EISSN: 1360-0443 ;DOI: 10.1111/j.1360-0443.2011.03515.x ;PMID: 21615585 ;CODEN: ADICE5

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
The impact of needle and syringe provision and opiate substitution therapy on the incidence of hepatitis C virus in injecting drug users: pooling of UK evidence
Author: Turner, Katy M. E. ; Hutchinson, Sharon ; Vickerman, Peter ; Hope, Vivian ; Craine, Noel ; Palmateer, Norah ; May, Margaret ; Taylor, Avril ; De Angelis, Daniela ; Cameron, Sheila ; Parry, John ; Lyons, Margaret ; Goldberg, David ; Allen, Elizabeth ; Hickman, Matthew
Subjects: Addictive behaviors ; Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Blood Diseases ; Disease control ; Disease Transmission, Infectious - prevention & control ; Drug Abuse ; Drug addiction ; Drug use ; Drug users ; Epidemiologic Methods ; Evidence ; Female ; Glasgow, Scotland ; Harm Reduction ; HCV ; Hepatitis ; Hepatitis C - epidemiology ; Hepatitis C - prevention & control ; Hepatitis C - transmission ; Hepatitis C virus ; Homelessness ; Humans ; Intervention ; Male ; Medical care ; Medical sciences ; Medical treatment ; Meta-analysis ; methadone ; Methadone - therapeutic use ; Miscellaneous ; Narcotics - therapeutic use ; needle and syringe programmes ; Needle exchange programs ; Needle Sharing - adverse effects ; Needle Sharing - statistics & numerical data ; Opiate Substitution Treatment ; Opiates ; Outcome Assessment (Health Care) ; Population ; Prevention and actions ; primary prevention ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Regression analysis ; Risk ; Sick Role ; Substance abuse treatment ; Substance Abuse, Intravenous - epidemiology ; Substance Abuse, Intravenous - rehabilitation ; Surveys ; Systematic review ; United Kingdom ; United Kingdom - epidemiology
Is Part Of: Addiction (Abingdon, England), 2011-11, Vol.106 (11), p.1978-1988
Description: ABSTRACT Aims To investigate whether opiate substitution therapy (OST) and needle and syringe programmes (NSP) can reduce hepatitis C virus (HCV) transmission among injecting drug users (IDUs). Design Meta‐analysis and pooled analysis, with logistic regression allowing adjustment for gender, injecting duration, crack injecting and homelessness. Setting Six UK sites (Birmingham, Bristol, Glasgow, Leeds, London and Wales), community recruitment. Participants A total of 2986 IDUs surveyed during 2001–09. Measurement Questionnaire responses were used to define intervention categories for OST (on OST or not) and high NSP coverage (≥100% versus <100% needles per injection). The primary outcome was new HCV infection, measured as antibody seroconversion at follow‐up or HCV antibody‐negative/RNA‐positive result in cross‐sectional surveys. Findings Preliminary meta‐analysis showed little evidence of heterogeneity between the studies on the effects of OST (I2 = 48%, P = 0.09) and NSP (I2 = 0%, P = 0.75), allowing data pooling. The analysis of both interventions included 919 subjects with 40 new HCV infections. Both receiving OST and high NSP coverage were associated with a reduction in new HCV infection [adjusted odds ratios (AORs) = 0.41, 95% confidence interval (CI): 0.21–0.82 and 0.48, 95% CI: 0.25–0.93, respectively]. Full harm reduction (on OST plus high NSP coverage) reduced the odds of new HCV infection by nearly 80% (AOR = 0.21, 95% CI: 0.08–0.52). Full harm reduction was associated with a reduction in self‐reported needle sharing by 48% (AOR 0.52, 95% CI: 0.32–0.83) and mean injecting frequency by 20.8 injections per month (95% CI: −27.3 to −14.4). Conclusions There is good evidence that uptake of opiate substitution therapy and high coverage of needle and syringe programmes can substantially reduce the risk of hepatitis C virus transmission among injecting drug users. Research is now required on whether the scaling‐up of intervention exposure can reduce and limit hepatitis C virus prevalence in this population.
Publisher: Oxford, UK: Blackwell Publishing Ltd
Language: English
Identifier: ISSN: 0965-2140
EISSN: 1360-0443
DOI: 10.1111/j.1360-0443.2011.03515.x
PMID: 21615585
CODEN: ADICE5
Source: MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

The impact of needle and syringe provision and opiate substitution therapy on the incidence of hepatitis C virus in injecting drug users: pooling of UK evidence

2011 The Authors, Addiction © 2011 Society for the Study of Addiction ;2015 INIST-CNRS ;2011 The Authors, Addiction © 2011 Society for the Study of Addiction. ;ISSN: 0965-2140 ;EISSN: 1360-0443 ;DOI: 10.1111/j.1360-0443.2011.03515.x ;PMID: 21615585 ;CODEN: ADICE5

Searching Remote Databases, Please Wait