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Most frequent South Asian haplotypes of ACE2 share identity by descent with East Eurasian populations

PloS one, 2020-09, Vol.15 (9), p.e0238255-e0238255 [Peer Reviewed Journal]

COPYRIGHT 2020 Public Library of Science ;COPYRIGHT 2020 Public Library of Science ;2020 Srivastava et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2020 Srivastava et al 2020 Srivastava et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0238255 ;PMID: 32936832

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Title:
Most frequent South Asian haplotypes of ACE2 share identity by descent with East Eurasian populations
Author: Srivastava, Anshika ; Pandey, Rudra Kumar ; Singh, Prajjval Pratap ; Kumar, Pramod ; Rasalkar, Avinash Arvind ; Tamang, Rakesh ; van Driem, George ; Shrivastava, Pankaj ; Chaubey, Gyaneshwer
Achilli, Alessandro
Subjects: ACE2 ; Analysis ; Angiotensin ; Angiotensin converting enzyme ; Angiotensin-Converting Enzyme 2 ; Asia - epidemiology ; Asian people ; Asian People - genetics ; Asians ; Betacoronavirus - physiology ; Biology and Life Sciences ; Computer and Information Sciences ; Coronaviridae ; Coronavirus Infections - ethnology ; Coronavirus Infections - genetics ; Coronaviruses ; COVID-19 ; Cytogenetics ; Demographic aspects ; Eurasians ; Genetic aspects ; Genetic susceptibility ; Genomes ; Haplotypes ; Haplotypes - genetics ; Health aspects ; Human Migration ; Humans ; Laboratories ; Linkage Disequilibrium ; Medicine and Health Sciences ; Minority & ethnic groups ; Pandemics ; People and Places ; Peptidyl-dipeptidase A ; Peptidyl-Dipeptidase A - genetics ; Phylogenetics ; Phylogeny ; Pneumonia, Viral - ethnology ; Pneumonia, Viral - genetics ; Polymorphism ; Polymorphism, Single Nucleotide ; Population ; Populations ; Receptors, Virus - genetics ; Risk factors ; SARS-CoV-2 ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Single-nucleotide polymorphism ; South Asians ; White People - genetics ; Zoology
Is Part Of: PloS one, 2020-09, Vol.15 (9), p.e0238255-e0238255
Description: It was shown that the human Angiotensin-converting enzyme 2 (ACE2) is the receptor of recent coronavirus SARS-CoV-2, and variation in this gene may affect the susceptibility of a population. Therefore, we have analysed the sequence data of ACE2 among 393 samples worldwide, focusing on South Asia. Genetically, South Asians are more related to West Eurasian populations rather than to East Eurasians. In the present analyses of ACE2, we observed that the majority of South Asian haplotypes are closer to East Eurasians rather than to West Eurasians. The phylogenetic analysis suggested that the South Asian haplotypes shared with East Eurasians involved two unique event polymorphisms (rs4646120 and rs2285666). In contrast with the European/American populations, both of the SNPs have largely similar frequencies for East Eurasians and South Asians, Therefore, it is likely that among the South Asians, host susceptibility to the novel coronavirus SARS-CoV-2 will be more similar to that of East Eurasians rather than to that of Europeans.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0238255
PMID: 32936832
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central
Coronavirus Research Database
Public Library of Science (PLoS)
ProQuest Central
DOAJ Directory of Open Access Journals

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Most frequent South Asian haplotypes of ACE2 share identity by descent with East Eurasian populations

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