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Sequence effects on internal structure of droplets of associative polymers

Biophysical journal, 2021-04, Vol.120 (7), p.1210-1218 [Peer Reviewed Journal]

2020 Biophysical Society ;Copyright © 2020 Biophysical Society. Published by Elsevier Inc. All rights reserved. ;2020 Biophysical Society. 2020 Biophysical Society ;ISSN: 0006-3495 ;EISSN: 1542-0086 ;DOI: 10.1016/j.bpj.2020.08.021 ;PMID: 32937111

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  • Title:
    Sequence effects on internal structure of droplets of associative polymers
  • Author: Singh, Kulveer ; Rabin, Yitzhak
  • Subjects: Gels ; Intrinsically Disordered Proteins ; Organelles ; Polymers ; Solvents
  • Is Part Of: Biophysical journal, 2021-04, Vol.120 (7), p.1210-1218
  • Description: Intrinsically disordered proteins (IDPs) can form liquid-like membraneless organelles, gels, and fibers in cells and in vitro. In this study, we propose a simple model of IDPs as associative polymers in poor solvent and explore the formation of transient liquid droplets and their transformation into solid-like aggregates. We use Langevin dynamics simulations of short polymers with two stickers placed symmetrically along their contour to study the effect of the primary sequence of these polymers on their organization inside condensed droplets. We observe that the shape, size, and number of sticker clusters inside the droplet change from a long cylindrical fiber to many compact clusters as one varies the location of stickers along the chain contour. Aging caused by the conversion of intramoleclular to intermolecular associations is observed in droplets of telechelic polymers but not for other sequences of associating polymers. The relevance of our results to condensates of IDPs is discussed.
  • Publisher: United States: Elsevier Inc
  • Language: English
  • Identifier: ISSN: 0006-3495
    EISSN: 1542-0086
    DOI: 10.1016/j.bpj.2020.08.021
    PMID: 32937111
  • Source: Cell Press Free Archives
    MEDLINE
    NCBI PubMed Central（免费）
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