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Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan

Fertility and sterility, 2014, Vol.101 (1), p.128-133 [Peer Reviewed Journal]

American Society for Reproductive Medicine ;2014 American Society for Reproductive Medicine ;Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. ;ISSN: 0015-0282 ;EISSN: 1556-5653 ;DOI: 10.1016/j.fertnstert.2013.09.025 ;PMID: 24268706

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Title:
Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan
Author: Ishihara, Osamu, M.D., Ph.D ; Araki, Ryuichiro, Ph.D ; Kuwahara, Akira, M.D., Ph.D ; Itakura, Atsuo, M.D., Ph.D ; Saito, Hidekazu, M.D., Ph.D ; Adamson, G. David, M.D
Subjects: Adult ; Cryopreservation - methods ; Embryo Transfer - adverse effects ; Embryo Transfer - methods ; Female ; Follow-Up Studies ; Frozen-thawed blastocyst transfer ; Humans ; Infant, Newborn ; Internal Medicine ; Japan - epidemiology ; Obstetrics and Gynecology ; placenta accreta ; Pregnancy ; Pregnancy Complications - diagnosis ; Pregnancy Complications - epidemiology ; Pregnancy Outcome ; pregnancy-induced hypertension ; Registries ; Retrospective Studies ; Single Embryo Transfer - adverse effects ; Single Embryo Transfer - methods
Is Part Of: Fertility and sterility, 2014, Vol.101 (1), p.128-133
Description: Objective To evaluate the relationship between frozen-thawed single blastocyst transfer (BT) and maternal and neonatal outcomes of pregnancy. Design Retrospective analysis. Setting Japanese nationwide registry of assisted reproductive technology (ART) with mandatory reporting for all ART clinics in Japan. Patient(s) Registered from 2008 through 2010 undergoing single embryo transfer cycles (n = 277,042). Intervention(s) None. Main Outcome Measure(s) Rates of preterm birth (PTB; <37 weeks' gestation), low birth weight (LBW; <2,500 g), small for gestational age (SGA), large for gestational age (LGA), placenta previa, placenta abruption, placenta accreta, and pregnancy-induced hypertension (PIH) after fresh/frozen-thawed and cleaved-embryo/blastocyst transfers were performed. Result(s) Frozen-thawed embryo transfer (FET) was associated with a significantly reduced occurrence of PTB, LBW, and SGA but increased rate of LGA. FET was also associated with a higher incidence of placenta accreta (odds ratio 3.16) and PIH (odds ratio 1.58). BT was associated with a significantly decreased rate of SGA and increased rate of LGA. There was no significant association between BT and maternal complications. Conclusion(s) Frozen-thawed BT is associated with improved general perinatal outcomes of pregnancy but significantly increased maternal risks of placenta accreta and PIH. This finding requires further investigation to assure maternal safety of patients undergoing ART treatment.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0015-0282
EISSN: 1556-5653
DOI: 10.1016/j.fertnstert.2013.09.025
PMID: 24268706
Source: MEDLINE
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Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan

American Society for Reproductive Medicine ;2014 American Society for Reproductive Medicine ;Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. ;ISSN: 0015-0282 ;EISSN: 1556-5653 ;DOI: 10.1016/j.fertnstert.2013.09.025 ;PMID: 24268706

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