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Adaptive immunity to SARS-CoV-2 and COVID-19

Cell, 2021-02, Vol.184 (4), p.861-880 [Peer Reviewed Journal]

2021 Elsevier Inc. ;Copyright © 2021 Elsevier Inc. All rights reserved. ;COPYRIGHT 2021 Elsevier B.V. ;2021. Not withstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://www.elsevier.com/legal/elsevier-website-terms-and-conditions ;2021 Elsevier Inc. 2021 Elsevier Inc. ;ISSN: 0092-8674 ;EISSN: 1097-4172 ;DOI: 10.1016/j.cell.2021.01.007 ;PMID: 33497610

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Title:
Adaptive immunity to SARS-CoV-2 and COVID-19
Author: Sette, Alessandro ; Crotty, Shane
Subjects: Adaptive Immunity ; Age Factors ; Antibodies ; Antigens ; B cells ; B-Lymphocytes - immunology ; Clinical Trials as Topic ; COVID-19 - complications ; COVID-19 - epidemiology ; COVID-19 - immunology ; COVID-19 - pathology ; COVID-19 - virology ; COVID-19 Vaccines - immunology ; Health aspects ; Humans ; Immunologic Memory ; Medical research ; Medicine, Experimental ; Post-Acute COVID-19 Syndrome ; Race Factors ; Review ; SARS-CoV-2 - classification ; SARS-CoV-2 - physiology ; Sex Factors ; T cells ; T-Lymphocyte Subsets - immunology ; Viral antibodies ; Viral Load ; Virus diseases
Is Part Of: Cell, 2021-02, Vol.184 (4), p.861-880
Description: The adaptive immune system is important for control of most viral infections. The three fundamental components of the adaptive immune system are B cells (the source of antibodies), CD4+ T cells, and CD8+ T cells. The armamentarium of B cells, CD4+ T cells, and CD8+ T cells has differing roles in different viral infections and in vaccines, and thus it is critical to directly study adaptive immunity to SARS-CoV-2 to understand COVID-19. Knowledge is now available on relationships between antigen-specific immune responses and SARS-CoV-2 infection. Although more studies are needed, a picture has begun to emerge that reveals that CD4+ T cells, CD8+ T cells, and neutralizing antibodies all contribute to control of SARS-CoV-2 in both non-hospitalized and hospitalized cases of COVID-19. The specific functions and kinetics of these adaptive immune responses are discussed, as well as their interplay with innate immunity and implications for COVID-19 vaccines and immune memory against re-infection. The adaptive immune system is crucial for controlling viral infection, but the kinetics and magnitude of the roles of its various components differ across viral infections. Review the emerging data on the roles of B cells, CD4+ T cells, and CD8+ T cells in SARS-CoV-2 infection.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0092-8674
EISSN: 1097-4172
DOI: 10.1016/j.cell.2021.01.007
PMID: 33497610
Source: Coronavirus Research Database

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Adaptive immunity to SARS-CoV-2 and COVID-19

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