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Tissue biology perspective on macrophages

Nature immunology, 2016-01, Vol.17 (1), p.9-17 [Peer Reviewed Journal]

COPYRIGHT 2016 Nature Publishing Group ;COPYRIGHT 2016 Nature Publishing Group ;Copyright Nature Publishing Group Jan 2016 ;ISSN: 1529-2908 ;EISSN: 1529-2916 ;DOI: 10.1038/ni.3320 ;PMID: 26681457

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  • Title:
    Tissue biology perspective on macrophages
  • Author: Okabe, Yasutaka ; Medzhitov, Ruslan
  • Subjects: Animals ; Developmental biology ; Health aspects ; Homeostasis - immunology ; Humans ; Immunity, Innate - immunology ; Macrophages ; Medical research ; Medicine, Experimental
  • Is Part Of: Nature immunology, 2016-01, Vol.17 (1), p.9-17
  • Description: Macrophages are essential components of mammalian tissues. Although historically known mainly for their function in host defense and the clearance of apoptotic cells, macrophages are now increasingly recognized as serving many roles in tissue development, homeostasis and repair. In addition, tissue-resident macrophages have many tissue-specific functional characteristics, which are a reflection of distinct gene-expression programs. Here we discuss the emerging views of macrophage biology from evolutionary, developmental and homeostatic perspectives.
  • Publisher: United States: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 1529-2908
    EISSN: 1529-2916
    DOI: 10.1038/ni.3320
    PMID: 26681457
  • Source: MEDLINE
    ProQuest Central
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