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Phenotypic divergence in sleep and circadian cycles linked by affective state and environmental risk related to psychosis

Sleep (New York, N.Y.), 2023-03, Vol.46 (3), p.1 [Peer Reviewed Journal]

Sleep Research Society 2022. Published by Oxford University Press on behalf of the Sleep Research Society. 2022 ;Sleep Research Society 2022. Published by Oxford University Press on behalf of the Sleep Research Society. ;COPYRIGHT 2023 Oxford University Press ;info:eu-repo/semantics/openAccess ;ISSN: 0161-8105 ;ISSN: 1550-9109 ;EISSN: 1550-9109 ;DOI: 10.1093/sleep/zsac311 ;PMID: 36516465

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  • Title:
    Phenotypic divergence in sleep and circadian cycles linked by affective state and environmental risk related to psychosis
  • Author: Purple, Ross J ; Cosgrave, Jan ; Alexander, Iona ; Middleton, Benita ; Foster, Russell G ; Porcheret, Kate ; Wulff, Katharina
  • Subjects: actigraphy ; Circadian Rhythm - physiology ; environmental risk factors ; Humans ; Insomnia and Psychiatric Disorders ; Market surveys ; Medical research ; Medicine, Experimental ; Melatonin ; Phenotype ; psychosis ; Psychotic Disorders - etiology ; Sleep ; Sleep - physiology ; sleep EEG
  • Is Part Of: Sleep (New York, N.Y.), 2023-03, Vol.46 (3), p.1
  • Description: Abstract Study Objectives Environmental cues influence circadian rhythm timing and neurochemicals involved in the regulation of affective behavior. How this interplay makes them a probable nonspecific risk factor for psychosis is unclear. We aimed to identify the relationship between environmental risk for psychosis and circadian timing phenotypes sampled from the general population. Methods Using an online survey, we devised a cumulative risk exposure score for each of the 1898 survey respondents based on 23 empirically verified transdiagnostic risks for psychosis, three dimensions of affect severity, psychotic-like experiences, and help-seeking behavior. Quantitative phenotyping of sleep and circadian rhythms was undertaken using at-home polysomnography, melatonin and cortisol profiles, and 3-week rest–activity behavior in individuals with a high-risk exposure load (top 15% of survey respondents, n = 22) and low-risk exposure load (bottom 15% of respondents, n = 22). Results Psychiatric symptoms were present in 100% of the high-load participants and 14% of the low-load participants. Compared to those with a low-load, high-load participants showed a later melatonin phase which was reflected by a greater degree of dispersion in circadian timing. Phase relationships between later circadian melatonin phase and later actigraphic sleep onsets were maintained and these were strongly correlated with self-reported sleep mid-points. No differences were identified from polysomnography during sleep between groups. Conclusion Distinguishing circadian timing from other sleep phenotypes will allow adaptation for dosage of time-directed intervention, useful in stabilizing circadian timekeeping physiology and potentially reducing the multisystemic disruption in mental health disorders. Graphical Abstract Graphical Abstract
  • Publisher: US: Oxford University Press
  • Language: English;Norwegian
  • Identifier: ISSN: 0161-8105
    ISSN: 1550-9109
    EISSN: 1550-9109
    DOI: 10.1093/sleep/zsac311
    PMID: 36516465
  • Source: ProQuest One Psychology
    AUTh Library subscriptions: ProQuest Central
    Oxford University Press Open Access
    MEDLINE
    NORA Norwegian Open Research Archives
    Alma/SFX Local Collection
    SWEPUB Freely available online
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