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Iron toxicity in neurodegeneration
Biometals, 2012-08, Vol.25 (4), p.761-776
[Peer Reviewed Journal]
Springer Science+Business Media, LLC. 2012 ;ISSN: 0966-0844 ;EISSN: 1572-8773 ;DOI: 10.1007/s10534-012-9523-0 ;PMID: 22318507
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Title:
Iron toxicity in neurodegeneration
Author:
Núñez, Marco T.
;
Urrutia, Pamela
;
Mena, Natalia
;
Aguirre, Pabla
;
Tapia, Victoria
;
Salazar, Julio
Subjects:
Animals
;
Biochemistry
;
Biomedical and Life Sciences
;
Cell Biology
;
Cellular biology
;
Glutathione - metabolism
;
Homeostasis
;
Humans
;
Iron
;
Iron - metabolism
;
Life Sciences
;
Medicine/Public Health
;
Microbiology
;
Mitochondria
;
Models, Biological
;
Neurobiology
;
Neurodegenerative Diseases - metabolism
;
Oxidative Stress - physiology
;
Pharmacology/Toxicology
;
Plant Physiology
;
Thermodynamics
;
Toxicity
Is Part Of:
Biometals, 2012-08, Vol.25 (4), p.761-776
Description:
Iron is an essential element for life on earth, participating in a plethora of cellular processes where one-electron transfer reactions are required. Its essentiality, coupled to its scarcity in aqueous oxidative environments, has compelled living organisms to develop mechanisms that ensure an adequate iron supply, at times with disregard to long-term deleterious effects derived from iron accumulation. However, iron is an intrinsic producer of reactive oxygen species, and increased levels of iron promote neurotoxicity because of hydroxyl radical formation, which results in glutathione consumption, protein aggregation, lipid peroxidation and nucleic acid modification. Neurons from brain areas sensitive to degeneration accumulate iron with age and thus are subjected to an ever increasing oxidative stress with the accompanying cellular damage. The ability of these neurons to survive depends on the adaptive mechanisms developed to cope with the increasing oxidative load. Here, we describe the chemical and thermodynamic peculiarities of iron chemistry in living matter, review the components of iron homeostasis in neurons and elaborate on the mechanisms by which iron homeostasis is lost in Parkinson’s disease, Alzheimer’s disease and other diseases in which iron accumulation has been demonstrated.
Publisher:
Dordrecht: Springer Netherlands
Language:
English;Dutch
Identifier:
ISSN: 0966-0844
EISSN: 1572-8773
DOI: 10.1007/s10534-012-9523-0
PMID: 22318507
Source:
AUTh Library subscriptions: ProQuest Central
MEDLINE
Alma/SFX Local Collection
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