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Changes in electrical activity of heart during ischemic–reperfusion injury modified by the administration of antidepressants

Acta Facultatis Pharmaceuticae Universitatis Comenianae, 2016-09, Vol.63 (1), p.5-8 [Peer Reviewed Journal]

Copyright De Gruyter Open Sp. z o.o. 2016 ;ISSN: 2453-6725 ;ISSN: 0301-2298 ;EISSN: 2453-6725 ;EISSN: 1338-6786 ;DOI: 10.1515/afpuc-2016-0006

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  • Title:
    Changes in electrical activity of heart during ischemic–reperfusion injury modified by the administration of antidepressants
  • Author: Vicen, M. ; Gulač, P. ; Stankovičová, T.
  • Subjects: amitriptylin ; Antidepressants ; Cardiovascular disease ; citalopram ; Ischemia ; Pharmacology ; venlafaxine
  • Is Part Of: Acta Facultatis Pharmaceuticae Universitatis Comenianae, 2016-09, Vol.63 (1), p.5-8
  • Description: Abstract The aim of our work was to investigate the effect of amitriptyline, citalopram and venlafaxine on the heart during ischemic- reperfusion (l-R) injury. Amitriptyline prolonged both QRS complex and QTc interval duration; citalopram and venlafaxine prolonged only QTc interval duration. Amitriptyline worked most proarrhythmogenic, citalopram least; venlafaxine increased the heart rate during ischemia; however, prolonged QTc interval at the beginning of reperfusion was followed by serious dysrhythmias.
  • Publisher: Bratislava: De Gruyter Poland
  • Language: English;Czech;German
  • Identifier: ISSN: 2453-6725
    ISSN: 0301-2298
    EISSN: 2453-6725
    EISSN: 1338-6786
    DOI: 10.1515/afpuc-2016-0006
  • Source: GFMER Free Medical Journals
    Alma/SFX Local Collection
    De Gruyter Open Access Journals
    DOAJ Directory of Open Access Journals
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