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Melatonin and cardiovascular disease: from mechanisms of action to potential clinical use (literature review)

Kardiovaskuli͡a︡rnai͡a︡ terapii͡a︡ i profilaktika, 2022-01, Vol.20 (8), p.2892 [Peer Reviewed Journal]

ISSN: 1728-8800 ;EISSN: 2619-0125 ;DOI: 10.15829/1728-8800-2021-2892

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  • Title:
    Melatonin and cardiovascular disease: from mechanisms of action to potential clinical use (literature review)
  • Author: Drapkina, O. M. ; Kontsevaya, A. V. ; Budnevsky, A. V. ; Ovsyannikov, E. S. ; Drobysheva, E. S. ; Bolotskih, V. I. ; Makeeva, A. V. ; Lushchik, M. V.
  • Subjects: антиоксидант ; атеросклероз ; мелатонин ; сердечная недостаточность
  • Is Part Of: Kardiovaskuli͡a︡rnai͡a︡ terapii͡a︡ i profilaktika, 2022-01, Vol.20 (8), p.2892
  • Description: Cardiovascular disease remains the most relevant public health problem. Most cardiovascular diseases are associated with an atherosclerosis, the development of which is associated with inflammation and endothelial dysfunction. Melatonin is a neurohormone that is synthesized mainly in the pineal gland and plays a central role in the regulation of sleep and some other body cyclic processes. For a long time, melatonin was perceived as a substance that is effective in the treatment of circadian cycle impairments. At the same time, a large number of studies have accumulated recently that demonstrate a wider range of its biological effects, including anti-inflammatory, antioxidant, antihypertensive and, possibly, hypolipidemic. The review includes current data from experimental and clinical studies demonstrating the cardioprotective effects of melatonin in atherosclerosis, myocardial ischemia, and heart failure.
  • Publisher: SILICEA-POLIGRAF» LLC
  • Language: English;Russian
  • Identifier: ISSN: 1728-8800
    EISSN: 2619-0125
    DOI: 10.15829/1728-8800-2021-2892
  • Source: DOAJ Directory of Open Access Journals
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