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Adenosine derivative, use thereof and pharmaceutical composition in which the derivative is comprised
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Title:
Adenosine derivative, use thereof and pharmaceutical composition in which the derivative is comprised
Author:
MYERS MICHAEL R
;
MAGUIRE MARTIN P
;
EWING WILLIAM R
;
CHOI-SLEDESKI YONG-MI
;
PAULS HENRY W
;
SPADA ALFRED P
Subjects:
CHEMISTRY
;
DERIVATIVES THEREOF
;
HETEROCYCLIC COMPOUNDS
;
HUMAN NECESSITIES
;
HYGIENE
;
MEDICAL OR VETERINARY SCIENCE
;
METALLURGY
;
NUCLEIC ACIDS
;
NUCLEOSIDES
;
NUCLEOTIDES
;
ORGANIC CHEMISTRY
;
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
;
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
;
SUGARS
Description:
Adenosinov deriv ty obecn ho vzorce I, jejich pou it pro l en kardiovaskul rn ch onemocn n , pro zm rn n ischemick ho poÜkozen nebo zmenÜen velikosti myokardi ln ho infarktu v d sledku myokardi ln ischemie, pro sn en hladiny lipid , triglycerid nebo cholesterolu u savc a pro l en kardiovaskul rn ho onemocn n nesouc ho stopy hypertenze nebo myokardi ln ischemie, zmenÜen velikosti myokardi ln ho infarktu v d sledku myokardi ln ischemie nebo pro sn en hladiny lipid , triglycerid nebo cholesterolu u savc . Pou it t chto slou enin pro v²robu l iva proti v²Üe uveden²m onemocn n m. Zp sob p° pravy uveden²ch slou enin.\ This invention relates to adenosine derivatives of the general formula I, their use for treating cardiovascular diseases, for ameliorating ischemic injury or reducing myocardial infarct size consequent to myocardial ischemia, further for reducing lipid levels, triglyceride levels, or cholesterol levels in a mammal, and for treating a cardiovascular disease bearing traces of hypertension or myocardial ischemia, reducing myocardial infarct size consequent to myocardial ischemia or for reducing lipid levels, triglyceride levels, or cholesterol levels in mammals. Disclosed is also the use of these derivatives for preparing a medicament used for treating the aforementioned diseases, as well as process for preparing these compounds.
Creation Date:
2003
Language:
Czech;English
Source:
esp@cenet
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