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First-trimester glycosylated hemoglobin in women at high risk for gestational diabetes

Acta obstetricia et gynecologica Scandinavica, 2016-01, Vol.95 (1), p.93-97 [Peer Reviewed Journal]

2015 Nordic Federation of Societies of Obstetrics and Gynecology ;2015 Nordic Federation of Societies of Obstetrics and Gynecology. ;Acta Obstetricia et Gynecologica Scandinavica © 2016 Nordic Federation of Societies of Obstetrics and Gynecology ;ISSN: 0001-6349 ;EISSN: 1600-0412 ;DOI: 10.1111/aogs.12784 ;PMID: 26400192 ;CODEN: AOGSAE

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Title:
First-trimester glycosylated hemoglobin in women at high risk for gestational diabetes
Author: Amylidi, Sofia ; Mosimann, Beatrice ; Stettler, Christoph ; Fiedler, Georg Martin ; Surbek, Daniel ; Raio, Luigi
Subjects: Adult ; Diabetes, Gestational - blood ; Diabetes, Gestational - diagnosis ; Diabetes, Gestational - epidemiology ; Female ; Gestational diabetes mellitus ; Glycated Hemoglobin A - metabolism ; glycosylated haemoglobin ; HbA1c ; high-risk pregnancy ; Humans ; Incidence ; oral glucose tolerance test ; Predictive Value of Tests ; Pregnancy ; Pregnancy Trimester, First - blood ; Pregnancy, High-Risk - blood ; Prevalence ; Retrospective Studies ; Risk Factors ; ROC Curve
Is Part Of: Acta obstetricia et gynecologica Scandinavica, 2016-01, Vol.95 (1), p.93-97
Description: Introduction Our aim was to investigate the prognostic value of first‐trimester glycosylated hemoglobin (HbA1c) in pregnant women with risk factors for developing gestational diabetes mellitus (GDM). Material and methods This is an observational retrospective cohort study conducted at the Department of Obstetrics and Gynecology, University Hospital Bern, Switzerland. We included pregnant women at high risk for GDM (n = 208), who had an HbA1c measurement in the first trimester. We compared HbA1c values of women who later developed GDM with those who did not develop GDM. Diagnosis of GDM was made on the basis of a 75‐g oral glucose tolerance test performed between 24 and 28 weeks of gestation. We further examined the prevalence of GDM in relation to the first‐trimester HbA1c value. Results The prevalence of GDM in our high‐risk group was 14.7%. Women who developed GDM had significantly higher first‐trimester HbA1c values [5.43 ± 0.31% (36 ± 3 mmol/mol) vs. 5.23 ± 0.28% (34 ± 3 mmol/mol); p = 0.0026]. Moreover, all pregnant women with HbA1c ≥6.0% (42 mmol/mol) developed GDM, whereas those with <4.5% (26 mmol/mol) did not. Conclusions Women at risk for GDM have higher first‐trimester HbA1c levels and values ≥6.0% (42 mmol/mol) are predictive of GDM. This information may be useful for counseling these women and providing appropriate advice on diet and lifestyle modification early in pregnancy.
Publisher: United States: Blackwell Publishing Ltd
Language: English;French;German
Identifier: ISSN: 0001-6349
EISSN: 1600-0412
DOI: 10.1111/aogs.12784
PMID: 26400192
CODEN: AOGSAE
Source: Journals@Ovid Open Access Journal Collection Rolling
MEDLINE
Alma/SFX Local Collection

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First-trimester glycosylated hemoglobin in women at high risk for gestational diabetes

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