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Association of uric acid in serum and urine with subclinical renal damage: Hanzhong Adolescent Hypertension Study

PloS one, 2019-11, Vol.14 (11), p.e0224680-e0224680 [Peer Reviewed Journal]

COPYRIGHT 2019 Public Library of Science ;COPYRIGHT 2019 Public Library of Science ;2019 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2019 Wang et al 2019 Wang et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0224680 ;PMID: 31730636

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Title:
Association of uric acid in serum and urine with subclinical renal damage: Hanzhong Adolescent Hypertension Study
Author: Wang, Yang ; Chen, Chen ; Yan, Yu ; Yuan, Yue ; Wang, Ke-Ke ; Chu, Chao ; Hu, Jia-Wen ; Ma, Qiong ; Liao, Yue-Yuan ; Fu, Bo-Wen ; Gao, Ke ; Sun, Yue ; Lv, Yong-Bo ; Zhu, Wen-Jing ; Yang, Lei ; Zhang, Jie ; Yang, Rui-Hai ; Yang, Jun ; Mu, Jian-Jun
Reboldi, Gianpaolo
Subjects: Acids ; Adolescent ; Adolescents ; Adult ; Albumin ; Albumins ; Analysis ; Biology and Life Sciences ; Biomarkers - blood ; Biomarkers - urine ; Cardiology ; Chen, Yu ; Child ; China - epidemiology ; Cohort Studies ; Creatinine ; Creatinine - blood ; Creatinine - urine ; Cross sections ; Cross-Sectional Studies ; Damage ; Diabetes ; Disease Progression ; Epidermal growth factor receptors ; Excretion ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Humans ; Hypertension ; Hypertension - blood ; Hypertension - complications ; Hypertension - epidemiology ; Hypertension - urine ; Incidence ; Kidney - pathology ; Kidney diseases ; Laboratories ; Longitudinal Studies ; Male ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Oxidative stress ; Physical Sciences ; Prognosis ; Prospective Studies ; Purines ; Renal function ; Renal Insufficiency, Chronic - blood ; Renal Insufficiency, Chronic - diagnosis ; Renal Insufficiency, Chronic - etiology ; Renal Insufficiency, Chronic - urine ; Risk ; Risk Factors ; Serum Albumin, Human - urine ; Studies ; Teenagers ; Uric acid ; Uric Acid - blood ; Uric Acid - urine ; Urine ; Wang, Chen ; Young Adult
Is Part Of: PloS one, 2019-11, Vol.14 (11), p.e0224680-e0224680
Description: The aim of the study was to examine the associations of uric acid (UA) in blood and urine with subclinical renal damage (SRD) and its progression in a Chinese cohort. 1) 2342 participants from our previously established cohort who were followed up in 2017 were included. Cross-sectional analysis was used to examine the relationships between serum and urinary UA and the risk of SRD. 2) A total of 266 participants were recruited from the same cohort in 2013, and followed up in 2017. Longitudinal analysis was used to determine the relationships of serum and urinary UA with progression of SRD, which was defined as urinary albumin-to-creatinine ratio (uACR) progression or estimated glomerular filtration rate (eGFR) decline. In cross-sectional analysis, higher levels of uACR were associated with higher levels of serum uric acid (SUA) and urinary uric acid/creatinine ratio (uUA/Cre). Lower eGFR was associated with higher levels of SUA and fractional excretion of uric acid (FEUA) but lower uUA/Cre levels in all subjects. In addition, the multivariate-adjusted odds ratios for SRD compared with non-SRD were 3.574 (2.255-5.664) for uUA/Cre. Increasing uUA/Cre levels were associated with higher risk of SRD. In longitudinal analysis, 4-year changes of uUA/Cre and SUA were significantly associated with eGFR decline. This study suggested that urinary UA excretion was significantly associated with the risk of SRD in Chinese adults. Furthermore, 4-year changes of serum and urinary UA were associated with SRD progression. These findings suggest that UA, especially urinary UA, may be used as a simple, noninvasive marker for early detection of decreased renal function in otherwise healthy subjects.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0224680
PMID: 31730636
Source: Public Library of Science (PLoS) Journals Open Access
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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Association of uric acid in serum and urine with subclinical renal damage: Hanzhong Adolescent Hypertension Study

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