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SIGNAL CONVERSION RECEPTOR AND USE THEREOF
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Title:
SIGNAL CONVERSION RECEPTOR AND USE THEREOF
Author:
JIN, Huajun
;
HUANG, Chen
;
WANG, Chao
;
GUO, Xiaochun
Subjects:
BEER
;
BIOCHEMISTRY
;
CHEMISTRY
;
COMPOSITIONS THEREOF
;
CULTURE MEDIA
;
ENZYMOLOGY
;
HUMAN NECESSITIES
;
HYGIENE
;
MEDICAL OR VETERINARY SCIENCE
;
METALLURGY
;
MICROBIOLOGY
;
MICROORGANISMS OR ENZYMES
;
MUTATION OR GENETIC ENGINEERING
;
ORGANIC CHEMISTRY
;
PEPTIDES
;
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
;
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
;
SPIRITS
;
VINEGAR
;
WINE
Description:
A signal conversion receptor and a use thereof. The signal conversion receptor comprises an extracellular domain of a receptor for an immunosuppressive cytokine or a functional fragment or a mutant thereof that retains the specific binding to the immunosuppressive cytokine; a transmembrane region or a mutant thereof; and an intracellular domain of a co-stimulatory signaling molecule or a functional fragment or a mutant thereof that retains the biological function of the co-stimulatory signaling molecule for transmitting co-stimulatory signals and activating immune cells. After being in contact with molecules on the tumor cell surface and/or tumor stromal cell surface playing an immunosuppressive role, the immune cells modified by the signal conversion receptor have an immune activation effect instead of being negatively affected by immunosuppressive molecules. In this way, the proliferation ability of the immune cells and the secretion function of cell factors are enhanced, and the survival time of the activa
Creation Date:
2021
Language:
Chinese;English;French
Source:
esp@cenet
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