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WP1-8 Radiographic markers of disturbances in CSF dynamics: correlating imaging with 24-hour ICP monitoring

Journal of neurology, neurosurgery and psychiatry, 2019-03, Vol.90 (3), p.e3-e4 [Peer Reviewed Journal]

2019, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions ;2019 2019, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions ;ISSN: 0022-3050 ;EISSN: 1468-330X ;DOI: 10.1136/jnnp-2019-ABN.10

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  • Title:
    WP1-8 Radiographic markers of disturbances in CSF dynamics: correlating imaging with 24-hour ICP monitoring
  • Author: Asif, H ; Craven, C ; Thorne, L ; Watkins, L ; Toma, A
  • Subjects: Morphology
  • Is Part Of: Journal of neurology, neurosurgery and psychiatry, 2019-03, Vol.90 (3), p.e3-e4
  • Description: ObjectivesDisorders with chronically elevated ICP have salient imaging findings associated with the sella turcica and optic nerves. We aim to quantify the degree of correlation between imaging features and ICP.DesignProspective case-cohort study.SubjectsOne-hundred and twenty-six patients (35M:91F) underwent ICPM with recent MR imaging.MethodsT1-saggital views for sella volume, optic nerve vertical tortuosity, then T2-axial views for optic nerve sheath distension were blindly reviewed against respective median ICP and pulse amplitudes (PA). Imaging was triple reviewed for discordant values.ResultsThe mean ICP of four sella morphologies (full/flat/concave/empty) were 1.2, 4.8, 8.4 and 16.7 mmHg respectively (p<0.01). AUROC for sella morphology predicting ICP was 0.81. This measurement was able to detect minimum ICP of 5.3 mmHg with 73.0% sensitivity and specificity, 73.0% PPV and 69.8% NPV. The mean PA values were 4.0, 5.2, 6.1 and 9.6 mmHg respectively (p<0.01). AUROC for sella morphology predicting PA was 0.78. This measurement was able to detect minimum PA of 5.47 mmHg with 76.3% sensitivity, 79.5% specificity, 63.5% PPV and 81.0% NPV. Mean PA values for vertical tortuosity (nil/uni/bi) were 5.2, 7.1 and 7.0 mmHg respectively (p<0.05). Mean ICP values for rail tracking (nil/uni/bi) were 4.5, 7.5 and 15.7 mmHg respectively (p<0.01). Mean PA values were 5.2, 5.8 and 8.0 mmHg respectively (p<0.0001).ConclusionsCombined radiological features of ICP are promising non-invasive markers for raised ICP.
  • Publisher: London: BMJ Publishing Group LTD
  • Language: English
  • Identifier: ISSN: 0022-3050
    EISSN: 1468-330X
    DOI: 10.1136/jnnp-2019-ABN.10
  • Source: ProQuest One Psychology
    ProQuest Central
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