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Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development

PLoS genetics, 2011-02, Vol.7 (2), p.e1001307-e1001307 [Peer Reviewed Journal]

COPYRIGHT 2011 Public Library of Science ;COPYRIGHT 2011 Public Library of Science ;Sovio et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 2011 ;2011 Sovio et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Sovio U, Mook-Kanamori DO, Warrington NM, Lawrence R, Briollais L, et al. (2011) Association between Common Variation at the FTO Locus and Changes in Body Mass Index from Infancy to Late Childhood: The Complex Nature of Genetic Association through Growth and Development. PLoS Genet 7(2): e1001307. doi:10.1371/journal.pgen.1001307 ;ISSN: 1553-7404 ;ISSN: 1553-7390 ;EISSN: 1553-7404 ;DOI: 10.1371/journal.pgen.1001307 ;PMID: 21379325

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Title:
Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development
Author: Sovio, Ulla ; Mook-Kanamori, Dennis O ; Warrington, Nicole M ; Lawrence, Robert ; Briollais, Laurent ; Palmer, Colin N A ; Cecil, Joanne ; Sandling, Johanna K ; Syvänen, Ann-Christine ; Kaakinen, Marika ; Beilin, Lawrie J ; Millwood, Iona Y ; Bennett, Amanda J ; Laitinen, Jaana ; Pouta, Anneli ; Molitor, John ; Davey Smith, George ; Ben-Shlomo, Yoav ; Jaddoe, Vincent W V ; Palmer, Lyle J ; Pennell, Craig E ; Cole, Tim J ; McCarthy, Mark I ; Järvelin, Marjo-Riitta ; Timpson, Nicholas J
Gibson, Greg
Subjects: Adiposity - genetics ; Adolescent ; Age ; Alleles ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO ; Body Height - genetics ; Body Mass Index ; Body Weight - genetics ; Child ; Child development ; Child, Preschool ; Councils ; Cross-Sectional Studies ; Diabetes ; Epidemiology ; Families & family life ; Female ; Genetic aspects ; Genetic Association Studies ; Genetic Loci - genetics ; Genetic Variation ; Genetics and Genomics/Complex Traits ; Genotype ; Genotype & phenotype ; Grants ; Growth and Development - genetics ; Health sciences ; Humans ; Infant ; Infant, Newborn ; Longitudinal Studies ; Male ; Medical research ; MEDICIN ; MEDICINE ; Meta-Analysis as Topic ; Metabolic disorders ; Obesity in children ; Polymorphism, Single Nucleotide - genetics ; Proteins - genetics ; Quantitative trait loci ; Risk factors ; Studies
Is Part Of: PLoS genetics, 2011-02, Vol.7 (2), p.e1001307-e1001307
Description: An age-dependent association between variation at the FTO locus and BMI in children has been suggested. We meta-analyzed associations between the FTO locus (rs9939609) and BMI in samples, aged from early infancy to 13 years, from 8 cohorts of European ancestry. We found a positive association between additional minor (A) alleles and BMI from 5.5 years onwards, but an inverse association below age 2.5 years. Modelling median BMI curves for each genotype using the LMS method, we found that carriers of minor alleles showed lower BMI in infancy, earlier adiposity rebound (AR), and higher BMI later in childhood. Differences by allele were consistent with two independent processes: earlier AR equivalent to accelerating developmental age by 2.37% (95% CI 1.87, 2.87, p = 10(-20)) per A allele and a positive age by genotype interaction such that BMI increased faster with age (p = 10(-23)). We also fitted a linear mixed effects model to relate genotype to the BMI curve inflection points adiposity peak (AP) in infancy and AR. Carriage of two minor alleles at rs9939609 was associated with lower BMI at AP (-0.40% (95% CI: -0.74, -0.06), p = 0.02), higher BMI at AR (0.93% (95% CI: 0.22, 1.64), p = 0.01), and earlier AR (-4.72% (-5.81, -3.63), p = 10(-17)), supporting cross-sectional results. Overall, we confirm the expected association between variation at rs9939609 and BMI in childhood, but only after an inverse association between the same variant and BMI in infancy. Patterns are consistent with a shift on the developmental scale, which is reflected in association with the timing of AR rather than just a global increase in BMI. Results provide important information about longitudinal gene effects and about the role of FTO in adiposity. The associated shifts in developmental timing have clinical importance with respect to known relationships between AR and both later-life BMI and metabolic disease risk.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1553-7404
ISSN: 1553-7390
EISSN: 1553-7404
DOI: 10.1371/journal.pgen.1001307
PMID: 21379325
Source: Public Library of Science (PLoS) Journals Open Access
PubMed (Medline)
Geneva Foundation Free Medical Journals at publisher websites
DOAJ Open Access Journals
MEDLINE
ProQuest Central

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Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development

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