skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Protection of homologous and heterologous boosters after primary schemes of rAd26-rAd5, ChAdOx1 nCoV-19 and BBIBP-CorV during the omicron outbreak in adults of 50 years and older in Argentina: a test-negative case–control studyResearch in context

Lancet Regional Health - Americas (Online), 2023-11, Vol.27, p.100607 [Peer Reviewed Journal]

ISSN: 2667-193X ;EISSN: 2667-193X

Full text available

Citations Cited by
  • Title:
    Protection of homologous and heterologous boosters after primary schemes of rAd26-rAd5, ChAdOx1 nCoV-19 and BBIBP-CorV during the omicron outbreak in adults of 50 years and older in Argentina: a test-negative case–control studyResearch in context
  • Author: Soledad González ; Santiago Olszevicki ; Alejandra Gaiano ; Martín Salazar ; Lorena Regairaz ; Ana Nina Varela Baino ; Erika Bartel ; Teresa Varela ; Veronica V. González Martínez ; Santiago Pesci ; Lupe Marín ; Juan Ignacio Irassar ; Leticia Ceriani ; Enio Garcia ; Nicolás Kreplak ; Elisa Estenssoro ; Franco Marsico
  • Subjects: Vaccination
  • Is Part Of: Lancet Regional Health - Americas (Online), 2023-11, Vol.27, p.100607
  • Description: Background: After primary vaccination schemes with rAd26-rAd5 (Sputnik V), ChAdOx1 nCoV-19, BBIBP-CorV or heterologous combinations, the effectiveness of homologous or heterologous boosters (Sputnik V, ChAdOx, Pfizer-BioNTech, Moderna) against SARS-CoV-2 infections, hospitalisations and deaths has been scarcely studied. Methods: Test-negative, case–control study, conducted in Argentina during omicron BA.1 predominance, in adults ≥50 years old tested for SARS-CoV-2 who had received two or three doses of COVID-19 vaccines. Outcomes were COVID-associated infections, hospitalisations and deaths after administering mRNA and vectored boosters, < or ≥60 days from the last dose. Findings: Of 422,124 individuals tested for SARS-CoV-2, 221,993 (52.5%) tested positive; 190,884 (45.2%) and 231,260 (54.8%) had received 2-dose and 3-dose vaccination schemes, respectively. The 3-dose scheme reduced infections, hospitalisations and death (OR 0.81 [0.80–0.83]; 0.28 [0.25–0.32] and 0.25 [0.22–0.28] respectively), but protection dropped after 60 days to 1.04 [1.01–1.06]; 0.52 [0.44–0.61] and 0.38 [0.33–0.45]). Compared with 2-dose-schemes, homologous boosters after primary schemes with vectored-vaccines provided lower protection against infections < and ≥60 days (0.94 [0.92–0.97] and 1.05 [1.01–1.09], respectively) but protected against hospitalisations (0.30 [0.26–0.35]) and deaths (0.29 [0.25–0.33]), decreasing after 60 days (0.59 [0.47–0.74] and 0.51 [0.41–0.64], respectively). Heterologous boosters protected against infections (0.70 [0.68–0.71]) but decreased after 60 days (1.01 [0.98–1.04]) and against hospitalisations and deaths (0.26 [0.22–0.31] and 0.22 [0.18–0.25], respectively), which also decreased after 60 days (0.43 [0.35–0.53] and 0.33 [0.26–0.41], respectively). Heterologous boosters protected against infections when applied <60 days (0.70 [0.68–0.71], p < 0.001), against hospitalisations when applied ≥60 days (0.43 [0.35–0.53], p < 0.01), and against deaths < and ≥60 days (0.22 [0.18–0.25], p < 0.01 and 0.33 [0.26–0.41], p < 0.001). Interpretation: During omicron predominance, heterologous boosters such as viral vectored and mRNA vaccines, following Sputnik V, ChAdOx1, Sinopharm or heterologous primary schemes might provide better protection against death; this effect might last longer in individuals aged ≥50 than homologous boosters. Funding: None.
  • Publisher: Elsevier
  • Language: English
  • Identifier: ISSN: 2667-193X
    EISSN: 2667-193X
  • Source: PubMed Central
    DOAJ Directory of Open Access Journals
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait