skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

H-ferritin and CD68 super(+)/H-ferritin super(+) monocytes/macrophages are increased in the skin of adult-onset Still's disease patients and correlate with the multi-visceral involvement of the disease

Clinical and experimental immunology, 2016-10, Vol.186 (1), p.30-38 [Peer Reviewed Journal]

ISSN: 0009-9104 ;EISSN: 1365-2249 ;DOI: 10.1111/cei.12826

Full text available

Citations Cited by
  • Title:
    H-ferritin and CD68 super(+)/H-ferritin super(+) monocytes/macrophages are increased in the skin of adult-onset Still's disease patients and correlate with the multi-visceral involvement of the disease
  • Author: Ruscitti, P ; Cipriani, P ; Ciccia, F ; Di Benedetto, P ; Liakouli, V ; Berardicurti, O ; Carubbi, F ; Guggino, G ; Di Bartolomeo, S ; Triolo, G ; Giacomelli, R
  • Subjects: Salmonidae
  • Is Part Of: Clinical and experimental immunology, 2016-10, Vol.186 (1), p.30-38
  • Description: Adult-onset Still's disease (AOSD) patients may show an evanescent salmon-pink erythema appearing during febrile attacks and reducing without fever. Some patients may experience this eruption for many weeks. During AOSD, exceptionally high serum levels of ferritin may be observed; it is an iron storage protein composed of 24 subunits, heavy (H) subunits and light (L) subunits. The ferritin enriched in L subunits (L-ferritin) and the ferritin enriched in H subunits (H-ferritin) may be observed in different tissues. In this work, we aimed to investigate the skin expression of both H-and L-ferritin and the number of macrophages expressing these molecules from AOSD patients with persistent cutaneous lesions. We observed an increased expression of H-ferritin in the skin, associated with an infiltrate in the biopsies obtained from persistent cutaneous lesions of AOSD patients. Furthermore, a positive correlation between H-ferritin skin levels as well as the number of CD68 super(+)/H-ferritin super(+) cells and the multi-visceral involvement of the disease was observed. Our data showed an increased expression of H-ferritin in the skin of AOSD patients, associated with a strong infiltrate of CD68 super(+)/H-ferritin super(+) cells. Furthermore, a correlation between the levels of H-ferritin as well as of the number of CD68 super(+)/H-ferritin super(+) cells and the multi-visceral involvement of the disease was observed.
  • Language: English
  • Identifier: ISSN: 0009-9104
    EISSN: 1365-2249
    DOI: 10.1111/cei.12826
  • Source: GFMER Free Medical Journals
    PubMed Central
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait