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Progress and prospects of early detection in lung cancer

Open biology, 2017-09, Vol.7 (9), p.170070 [Peer Reviewed Journal]

2017 The Authors. ;2017 The Authors. 2017 ;ISSN: 2046-2441 ;EISSN: 2046-2441 ;DOI: 10.1098/rsob.170070 ;PMID: 28878044

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Title:
Progress and prospects of early detection in lung cancer
Author: Blandin Knight, Sean ; Crosbie, Phil A. ; Balata, Haval ; Chudziak, Jakub ; Hussell, Tracy ; Dive, Caroline
Subjects: Adenocarcinoma - diagnostic imaging ; Adenocarcinoma - genetics ; Adenocarcinoma - mortality ; Adenocarcinoma - surgery ; Adenocarcinoma of Lung ; Biomarkers, Tumor - blood ; Biomarkers, Tumor - genetics ; Bronchoscopy - methods ; Carcinoma, Non-Small-Cell Lung - diagnostic imaging ; Carcinoma, Non-Small-Cell Lung - genetics ; Carcinoma, Non-Small-Cell Lung - mortality ; Carcinoma, Non-Small-Cell Lung - surgery ; Carcinoma, Squamous Cell - diagnostic imaging ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - surgery ; Circulating Tumor DNA - blood ; Circulating Tumor DNA - genetics ; Early Detection of Cancer - methods ; Humans ; Liquid Biopsy - methods ; Low-Dose Ct Screening ; Lung Cancer ; Lung Neoplasms - diagnostic imaging ; Lung Neoplasms - genetics ; Lung Neoplasms - mortality ; Lung Neoplasms - surgery ; Neoplasm Staging ; Neoplastic Cells, Circulating - metabolism ; Neoplastic Cells, Circulating - pathology ; Nlst Trial ; Prognosis ; Radiography ; Review ; Small Cell Lung Carcinoma - diagnostic imaging ; Small Cell Lung Carcinoma - genetics ; Small Cell Lung Carcinoma - mortality ; Small Cell Lung Carcinoma - surgery ; Survival Analysis
Is Part Of: Open biology, 2017-09, Vol.7 (9), p.170070
Description: Lung cancer is the leading cause of cancer-related death in the world. It is broadly divided into small cell (SCLC, approx. 15% cases) and non-small cell lung cancer (NSCLC, approx. 85% cases). The main histological subtypes of NSCLC are adenocarcinoma and squamous cell carcinoma, with the presence of specific DNA mutations allowing further molecular stratification. If identified at an early stage, surgical resection of NSCLC offers a favourable prognosis, with published case series reporting 5-year survival rates of up to 70% for small, localized tumours (stage I). However, most patients (approx. 75%) have advanced disease at the time of diagnosis (stage III/IV) and despite significant developments in the oncological management of late stage lung cancer over recent years, survival remains poor. In 2014, the UK Office for National Statistics reported that patients diagnosed with distant metastatic disease (stage IV) had a 1-year survival rate of just 15–19% compared with 81–85% for stage I.
Publisher: England: The Royal Society
Language: English
Identifier: ISSN: 2046-2441
EISSN: 2046-2441
DOI: 10.1098/rsob.170070
PMID: 28878044
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
DOAJ: Directory of Open Access Journals
ROAD: Directory of Open Access Scholarly Resources

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Progress and prospects of early detection in lung cancer

2017 The Authors. ;2017 The Authors. 2017 ;ISSN: 2046-2441 ;EISSN: 2046-2441 ;DOI: 10.1098/rsob.170070 ;PMID: 28878044

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