Language:

Lung Cancer Incidence and Mortality with Extended Follow-up in the National Lung Screening Trial

Journal of thoracic oncology, 2019-10, Vol.14 (10), p.1732-1742 [Peer Reviewed Journal]

2019 ;Copyright © 2019 by the International Association for the Study of Lung Cancer ;Published by Elsevier Inc. ;ISSN: 1556-0864 ;EISSN: 1556-1380 ;DOI: 10.1016/j.jtho.2019.05.044 ;PMID: 31260833

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Lung Cancer Incidence and Mortality with Extended Follow-up in the National Lung Screening Trial
Author: The National Lung Screening Trial Research Team ; National Lung Screening Trial Research Team
Subjects: Adenocarcinoma of Lung - diagnosis ; Adenocarcinoma of Lung - epidemiology ; Adenocarcinoma of Lung - mortality ; Adenocarcinoma of Lung - therapy ; Aged ; Carcinoma, Large Cell - diagnosis ; Carcinoma, Large Cell - epidemiology ; Carcinoma, Large Cell - mortality ; Carcinoma, Large Cell - therapy ; Carcinoma, Non-Small-Cell Lung - diagnosis ; Carcinoma, Non-Small-Cell Lung - epidemiology ; Carcinoma, Non-Small-Cell Lung - mortality ; Carcinoma, Non-Small-Cell Lung - therapy ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - epidemiology ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - therapy ; Early Detection of Cancer - methods ; Female ; Follow-Up Studies ; Humans ; Incidence ; Low-dose CT ; Lung cancer ; Lung Neoplasms - diagnosis ; Lung Neoplasms - epidemiology ; Lung Neoplasms - mortality ; Lung Neoplasms - therapy ; Male ; Middle Aged ; Mortality ; Prognosis ; Screening ; Small Cell Lung Carcinoma - diagnosis ; Small Cell Lung Carcinoma - epidemiology ; Small Cell Lung Carcinoma - mortality ; Small Cell Lung Carcinoma - therapy ; Survival Rate ; United States - epidemiology
Is Part Of: Journal of thoracic oncology, 2019-10, Vol.14 (10), p.1732-1742
Description: The National Lung Screening Trial (NLST) randomized high-risk current and former smokers to three annual screens with either low-dose computed tomography (LDCT) or chest radiography (CXR) and demonstrated a significant reduction in lung cancer mortality in the LDCT arm after a median of 6.5 years' follow-up. We report on extended follow-up of NLST subjects. Subjects were followed by linkage to state cancer registries and the National Death Index. The number needed to screen (NNS) to prevent one lung cancer death was computed as the reciprocal of the difference in the proportion of patients dying of lung cancer across arms. Lung cancer mortality rate ratios (RRs) were computed overall and adjusted for dilution effect, with the latter including only deaths with a corresponding diagnosis close enough to the end of protocol screening. The median follow-up times were 11.3 years for incidence and 12.3 years for mortality. In all, 1701 and 1681 lung cancers were diagnosed in the LDCT and CXR arms, respectively (RR = 1.01, 95% confidence interval [CI]: 0.95–1.09). The observed numbers of lung cancer deaths were 1147 (with LDCT) versus 1236 (with CXR) (RR = 0.92, 95% CI: 0.85–1.00). The difference in the number of patients dying of lung cancer (per 1000) across arms was 3.3, translating into an NNS of 303, which is similar to the original NNS estimate of around 320. The dilution-adjusted lung cancer mortality RR was 0.89 (95% CI: 0.80–0.997). With regard to overall mortality, there were 5253 (with LDCT) and 5366 (with CXR) deaths, for a difference across arms (per 1000) of 4.2 (95% CI: –2.6 to 10.9). Extended follow-up of the NLST showed an NNS similar to that of the original analysis. There was no overall increase in lung cancer incidence in the LDCT arm versus in the CXR arm.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 1556-0864
EISSN: 1556-1380
DOI: 10.1016/j.jtho.2019.05.044
PMID: 31260833
Source: MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Lung Cancer Incidence and Mortality with Extended Follow-up in the National Lung Screening Trial

2019 ;Copyright © 2019 by the International Association for the Study of Lung Cancer ;Published by Elsevier Inc. ;ISSN: 1556-0864 ;EISSN: 1556-1380 ;DOI: 10.1016/j.jtho.2019.05.044 ;PMID: 31260833

Searching Remote Databases, Please Wait