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Cost-effectiveness of genotyping to guide treatment
Pharmacogenomics, 2014-04, Vol.15 (6), p.727-729
[Peer Reviewed Journal]
COPYRIGHT 2014 Future Medicine Ltd. ;Copyright Future Medicine Ltd Apr 2014 ;ISSN: 1462-2416 ;EISSN: 1744-8042 ;DOI: 10.2217/pgs.14.24 ;PMID: 24897279
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Title:
Cost-effectiveness of genotyping to guide treatment
Author:
Sorich, Michael J
;
Wiese, Michael D
;
Pekarsky, Brita
Subjects:
Breast cancer
;
Chemotherapy
;
clinical translation
;
clinical utility
;
Cost analysis
;
Cost control
;
Cost-Benefit Analysis - economics
;
cost-effectiveness
;
Decision making
;
Delivery of Health Care - economics
;
Drug therapy
;
Drug Therapy - economics
;
Electronic medical records
;
evidence
;
Gene expression
;
Genomes
;
Genotype
;
Genotype & phenotype
;
Genotyping
;
Humans
;
pharmacogenetics
;
Pharmacogenetics - economics
;
Pharmacogenomics
;
prioritization
;
Rheumatoid arthritis
;
xxx
Is Part Of:
Pharmacogenomics, 2014-04, Vol.15 (6), p.727-729
Description:
Here we will highlight and briefly explore four key issues relating to the cost-effectiveness of pharmacogenomics: ▪The relationship between clinical utility and cost-effectiveness; ▪Cost-effectiveness and the prioritization of pharmacogenomics research; ▪Time dependency of cost-effectiveness estimates; ▪Whether pharmacogenomics will reduce costs to the healthcare system. Clinical utility is a key characteristic underlying the success of a pharmacogenomic marker, and we have found that the relationship between clinical utility and cost-effectiveness is an important aspect of assessing the face value of CEAs. [...]it may also be pertinent to consider whether the cost of the test itself may change over time, and the impact of alternative testing strategies that may become more prominent in the future (e.g., whole genome stored in an electronic health record). An example is the OncotypeDx® assay for early breast cancer, which is a relatively complex gene-expression profile that is priced at a few thousand dollars per test [15]. [...]any savings generated from avoiding chemotherapy are at least partially offset by the cost of undertaking the assay.
Publisher:
England: Future Medicine Ltd
Language:
English
Identifier:
ISSN: 1462-2416
EISSN: 1744-8042
DOI: 10.2217/pgs.14.24
PMID: 24897279
Source:
MEDLINE
ProQuest Central
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