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Ticagrelor versus Clopidogrel in Symptomatic Peripheral Artery Disease

The New England journal of medicine, 2017-01, Vol.376 (1), p.32-40 [Peer Reviewed Journal]

Copyright © 2016 Massachusetts Medical Society. All rights reserved. ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0028-4793 ;ISSN: 1533-4406 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1611688 ;PMID: 27959717

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Title:
Ticagrelor versus Clopidogrel in Symptomatic Peripheral Artery Disease
Author: Hiatt, William R ; Fowkes, F. Gerry R ; Heizer, Gretchen ; Berger, Jeffrey S ; Baumgartner, Iris ; Held, Peter ; Katona, Brian G ; Mahaffey, Kenneth W ; Norgren, Lars ; Jones, W. Schuyler ; Blomster, Juuso ; Millegård, Marcus ; Reist, Craig ; Patel, Manesh R
Subjects: Adenosine - adverse effects ; Adenosine - analogs & derivatives ; Adenosine - therapeutic use ; Aged ; Ankle ; Arteriosclerosis ; Aspirin ; Bleeding ; Cardiac and Cardiovascular Systems ; Cardiovascular diseases ; Cardiovascular Diseases - mortality ; Cardiovascular Diseases - prevention & control ; Care and treatment ; Cerebral infarction ; Clinical Medicine ; Clinical outcomes ; Clinical trials ; Clopidogrel ; Comparative analysis ; Comparative studies ; Diagnosis ; Double-Blind Method ; Drug therapy ; Female ; Hemorrhage - chemically induced ; Human health and pathology ; Humans ; Intermittent Claudication - drug therapy ; Ischemia ; Ischemia - drug therapy ; Kaplan-Meier Estimate ; Kardiologi ; Klinisk medicin ; Leg - blood supply ; Life Sciences ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Middle Aged ; Myocardial infarction ; Peripheral Arterial Disease - drug therapy ; Peripheral vascular diseases ; Pharmaceuticals ; Platelet Aggregation Inhibitors - adverse effects ; Platelet Aggregation Inhibitors - therapeutic use ; Purinergic P2Y Receptor Antagonists - therapeutic use ; Ticagrelor ; Ticlopidine - adverse effects ; Ticlopidine - analogs & derivatives ; Ticlopidine - therapeutic use ; Vascular diseases ; Vein & artery diseases
Is Part Of: The New England journal of medicine, 2017-01, Vol.376 (1), p.32-40
Description: In this randomized trial involving 13,885 patients with symptomatic peripheral artery disease (PAD), ticagrelor was not shown to be superior to clopidogrel for the reduction of cardiovascular events. Major bleeding occurred at similar rates with ticagrelor and clopidogrel. Peripheral artery disease is considered to be a clinical manifestation of systemic atherosclerosis affecting the vascular territories supplying the lower limbs. Most patients presenting with peripheral artery disease do not have a clinical history of cardiac or cerebral ischemic events, yet these patients are at high risk for myocardial infarction, ischemic stroke, and cardiovascular death. 1 Concomitant clinical evidence of coronary or cerebrovascular disease only magnifies this risk. 2 Therapies to reduce the ischemic risk associated with atherosclerosis have focused on patients with acute coronary syndromes and stable coronary artery disease. Antithrombotic drugs, mainly antiplatelet therapies and statins, are the cornerstone of . . .
Publisher: United States: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
ISSN: 1533-4406
EISSN: 1533-4406
DOI: 10.1056/NEJMoa1611688
PMID: 27959717
Source: ProQuest One Psychology
AUTh Library subscriptions: ProQuest Central
MEDLINE
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Ticagrelor versus Clopidogrel in Symptomatic Peripheral Artery Disease

Copyright © 2016 Massachusetts Medical Society. All rights reserved. ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0028-4793 ;ISSN: 1533-4406 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1611688 ;PMID: 27959717

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