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Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction

The New England journal of medicine, 2015-05, Vol.372 (19), p.1791-1800 [Peer Reviewed Journal]

Copyright © 2015 Massachusetts Medical Society. All rights reserved. ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0028-4793 ;ISSN: 1533-4406 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1500857 ;PMID: 25773268

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Title:
Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction
Author: Bonaca, Marc P ; Bhatt, Deepak L ; Cohen, Marc ; Steg, Philippe Gabriel ; Storey, Robert F ; Jensen, Eva C ; Magnani, Giulia ; Bansilal, Sameer ; Fish, M. Polly ; Im, Kyungah ; Bengtsson, Olof ; Ophuis, Ton Oude ; Budaj, Andrzej ; Theroux, Pierre ; Ruda, Mikhail ; Hamm, Christian ; Goto, Shinya ; Spinar, Jindrich ; Nicolau, José Carlos ; Kiss, Robert G ; Murphy, Sabina A ; Wiviott, Stephen D ; Held, Peter ; Braunwald, Eugene ; Sabatine, Marc S
Subjects: Adenosine - administration & dosage ; Adenosine - adverse effects ; Adenosine - analogs & derivatives ; Adenosine/administration & dosage/adverse effects/analogs & derivatives ; Aged ; Analysis ; Antagonist drugs ; Aspirin ; Aspirin - administration & dosage ; Bleeding ; Blood platelets ; Cardiovascular & respiratory systems ; Cardiovascular diseases ; Cardiovascular Diseases - mortality ; Cardiovascular Diseases - prevention & control ; Cardiovascular Diseases/mortality/prevention & control ; Care and treatment ; Cerebral infarction ; Dosage and administration ; Dose-response relationship (Biochemistry) ; Double-Blind Method ; Drug Administration Schedule ; Drug therapy ; Drug Therapy, Combination ; Female ; Heart attack ; Heart attacks ; Hemorrhage ; Hemorrhage - chemically induced ; Human health and pathology ; Human health sciences ; Humans ; Intracranial Hemorrhages - chemically induced ; Kaplan-Meier Estimate ; Life Sciences ; Long term ; Male ; Medicin och hälsovetenskap ; Middle Aged ; Myocardial infarction ; Myocardial Infarction - drug therapy ; Patients ; Platelet Aggregation Inhibitors - administration & dosage ; Platelet Aggregation Inhibitors - adverse effects ; Platelet Aggregation Inhibitors/administration & dosage/adverse effects ; Purinergic P2Y Receptor Antagonists - administration & dosage ; Purinergic P2Y Receptor Antagonists - adverse effects ; Purinergic P2Y Receptor Antagonists/administration & dosage/adverse effects ; Risk ; Risk factors ; Safety and security measures ; Sciences de la santé humaine ; Secondary Prevention ; Stroke ; Systèmes cardiovasculaire & respiratoire ; Thrombolysis ; Ticagrelor ; Treatment outcome
Is Part Of: The New England journal of medicine, 2015-05, Vol.372 (19), p.1791-1800
Description: Patients with myocardial infarction 1 to 3 years previously were assigned to ticagrelor, 90 or 60 mg twice daily, or to placebo, in addition to low-dose aspirin. At 3 years, ticagrelor reduced the risk of cardiovascular death, MI, or stroke but increased the risk of major bleeding. Myocardial infarction is a global problem. 1 In the United States alone, nearly 8 million people have a history of myocardial infarction. 2 Patients who have had a myocardial infarction are at heightened risk for recurrent ischemic events, 3 – 5 which suggests that this population may derive particular benefit from intensive secondary prevention. A key element in the pathobiology of cardiovascular ischemic events is the activated platelet. 6 Aspirin reduces the risk of ischemic events both among patients who present with an acute coronary syndrome and in secondary prevention for patients with a history of myocardial infarction. 7 The addition of a P2Y 12 receptor . . .
Publisher: United States: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
ISSN: 1533-4406
EISSN: 1533-4406
DOI: 10.1056/NEJMoa1500857
PMID: 25773268
Source: ProQuest One Psychology
AUTh Library subscriptions: ProQuest Central
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Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction

Copyright © 2015 Massachusetts Medical Society. All rights reserved. ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0028-4793 ;ISSN: 1533-4406 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1500857 ;PMID: 25773268

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