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Comparative sequence analysis of the non-protein-coding mitochondrial DNA of inbred rat strains

PloS one, 2009-12, Vol.4 (12), p.e8148-e8148 [Peer Reviewed Journal]

COPYRIGHT 2009 Public Library of Science ;2009 Abhyankar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Abhyankar et al. 2009 ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0008148 ;PMID: 19997590

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Title:
Comparative sequence analysis of the non-protein-coding mitochondrial DNA of inbred rat strains
Author: Abhyankar, Avinash ; Park, Hee-Bok ; Tonolo, Giancarlo ; Luthman, Holger
Orban, Laszlo
Subjects: Animals ; Base Sequence ; Basic Medicine ; Biological evolution ; Biosynthesis ; Clinical Medicine ; Deoxyribonucleic acid ; DNA ; DNA, Mitochondrial - chemistry ; DNA, Mitochondrial - genetics ; Evolutionary Biology/Evolutionary and Comparative Genetics ; Evolutionary genetics ; Gene expression ; Genes ; Genetics ; Genetics and Genomics/Comparative Genomics ; Genomes ; Genomics ; Hypotheses ; Inbreeding ; Klinisk medicin ; Marsupials ; Medical and Health Sciences ; Medical Genetics ; Medicin och hälsovetenskap ; Medicinsk genetik ; Medicinska och farmaceutiska grundvetenskaper ; Mitochondria ; Mitochondrial DNA ; Molecular Biology/Molecular Evolution ; Molecular Sequence Data ; Mutation ; Neutrality ; Nucleic Acid Conformation ; Nucleotide sequence ; Open Reading Frames - genetics ; Phylogenetics ; Population growth ; Proteins ; Rats ; Rats, Inbred Strains - genetics ; Rattus norvegicus ; RNA, Ribosomal - chemistry ; RNA, Ribosomal - genetics ; RNA, Transfer - chemistry ; RNA, Transfer - genetics ; rRNA 12S ; rRNA 16S ; Selection, Genetic ; Sequence Analysis, DNA ; Statistical analysis ; Transfer RNA ; tRNA Cys
Is Part Of: PloS one, 2009-12, Vol.4 (12), p.e8148-e8148
Description: The proper function of mammalian mitochondria necessitates a coordinated expression of both nuclear and mitochondrial genes, most likely due to the co-evolution of nuclear and mitochondrial genomes. The non-protein coding regions of mitochondrial DNA (mtDNA) including the D-loop, tRNA and rRNA genes form a major component of this regulated expression unit. Here we present comparative analyses of the non-protein-coding regions from 27 Rattus norvegicus mtDNA sequences. There were two variable positions in 12S rRNA, 20 in 16S rRNA, eight within the tRNA genes and 13 in the D-loop. Only one of the three neutrality tests used demonstrated statistically significant evidence for selection in 16S rRNA and tRNA-Cys. Based on our analyses of conserved sequences, we propose that some of the variable nucleotide positions identified in 16S rRNA and tRNA-Cys, and the D-loop might be important for mitochondrial function and its regulation.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0008148
PMID: 19997590
Source: Public Library of Science (PLoS) Journals Open Access
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
SWEPUB Freely available online
ProQuest Central
DOAJ Directory of Open Access Journals

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Comparative sequence analysis of the non-protein-coding mitochondrial DNA of inbred rat strains

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