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Mood-elevating effects of d -amphetamine and incentive salience: the effect of acute dopamine precursor depletion

Journal of psychiatry & neuroscience, 2007-03, Vol.32 (2), p.129-136 [Peer Reviewed Journal]

Canadian Medical Association ;2007 INIST-CNRS ;COPYRIGHT 2007 CMA Impact Inc. ;COPYRIGHT 2007 Joule Inc. ;Copyright Canadian Medical Association Mar 2007 ;2007 Canadian Medical Association ;ISSN: 1180-4882 ;EISSN: 1488-2434 ;DOI: 10.1016/S1180-4882(07)50017-X ;PMID: 17353942 ;CODEN: JPNEEF

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Title:
Mood-elevating effects of d -amphetamine and incentive salience: the effect of acute dopamine precursor depletion
Author: Leyton, Marco, PhD ; Marije aan het, R.o., MSc ; Booij, Linda, PhD ; Young, Simon N., PhD ; Benkelfat, Chawki, MD, DERBH ; Baker, Glen B., PhD, DSc
Subjects: Adult ; Affect - drug effects ; Amphetamines ; Attention - drug effects ; Biological and medical sciences ; Carbidopa - pharmacology ; Central Nervous System Stimulants - pharmacology ; Depression, Mental ; Dextroamphetamine ; Dextroamphetamine - pharmacology ; Dopamine ; Dopamine - metabolism ; Double-Blind Method ; Drug Combinations ; Drug therapy ; Fundamental and applied biological sciences. Psychology ; Humans ; Levodopa - pharmacology ; Male ; Medical Education ; Medical sciences ; Men ; Motivation ; Neuropsychological Tests ; Neurotransmitters ; Pain Measurement ; Phenylalanine - deficiency ; Psychiatric research ; Psychiatry ; Psychoanalysis ; Psychological aspects ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. Psychiatry ; Reaction Time - drug effects ; Research Paper ; Studies ; Tyrosine - deficiency
Is Part Of: Journal of psychiatry & neuroscience, 2007-03, Vol.32 (2), p.129-136
Description: Objective Midbrain dopamine transmission is thought to regulate responses to rewarding drugs and drug-paired stimuli; however, the exact contribution, particularly in humans, remains unclear. In the present study, we tested whether decreasing dopamine synthesis, as produced by acute phenylalanine/tyrosine depletion (APTD), would alter responses to the stimulant drug, d-amphetamine. Methods On 3 separate days, 14 healthy men received d-amphetamine (0.3 mg/kg, given orally) plus a nutritionally balanced amino acid mixture, the phenylalanine/tyrosine-deficient mixture or the phenylalanine/tyrosine-deficient mixture followed by the immediate dopamine precursor, L-DOPA (Sinemet, 2 × 100 mg/25 mg). Responses to these treatments were assessed with visual analog scales, the Profile of Mood States, and a computerized Go/No-Go task. Results d-Amphetamine elicited its prototypical subjective effects, but these were not altered by APTD. In comparison, APTD significantly increased commission errors on the Go/No-Go task and did so uniquely in conditions where subjects were rewarded for making correct responses; this effect of APTD was prevented by L-DOPA. Conclusions Together these results support the hypothesis that, in healthy men, dopamine is not closely linked to euphorogenic effects of abused substances but does affect the salience of reward-related cues and the ability to respond to them preferentially.
Publisher: Ottawa, ON: Canadian Medical Association
Language: French;English
Identifier: ISSN: 1180-4882
EISSN: 1488-2434
DOI: 10.1016/S1180-4882(07)50017-X
PMID: 17353942
CODEN: JPNEEF
Source: ProQuest One Psychology
GFMER Free Medical Journals
MEDLINE
PubMed Central
Alma/SFX Local Collection
ProQuest Central

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Mood-elevating effects of d -amphetamine and incentive salience: the effect of acute dopamine precursor depletion

Canadian Medical Association ;2007 INIST-CNRS ;COPYRIGHT 2007 CMA Impact Inc. ;COPYRIGHT 2007 Joule Inc. ;Copyright Canadian Medical Association Mar 2007 ;2007 Canadian Medical Association ;ISSN: 1180-4882 ;EISSN: 1488-2434 ;DOI: 10.1016/S1180-4882(07)50017-X ;PMID: 17353942 ;CODEN: JPNEEF

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