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Copper(II) complexes with naringenin and hesperetin: cytotoxic activity against A 549 human lung adenocarcinoma cells and investigation on the mode of action

Biometals, 2016-02, Vol.29 (1), p.39-52 [Peer Reviewed Journal]

Springer Science+Business Media New York 2015 ;Springer Science+Business Media New York 2016 ;ISSN: 0966-0844 ;EISSN: 1572-8773 ;DOI: 10.1007/s10534-015-9894-0 ;PMID: 26582127

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Title:
Copper(II) complexes with naringenin and hesperetin: cytotoxic activity against A 549 human lung adenocarcinoma cells and investigation on the mode of action
Author: Tamayo, Lenka V. ; Gouvea, Ligiane R. ; Sousa, Anna C. ; Albuquerque, Ronniel M. ; Teixeira, Sarah Fernandes ; de Azevedo, Ricardo Alexandre ; Louro, Sonia R. W. ; Ferreira, Adilson Kleber ; Beraldo, Heloisa
Subjects: Adenocarcinoma - chemistry ; Adenocarcinoma - drug therapy ; Adenocarcinoma of Lung ; Antineoplastic Agents - administration & dosage ; Antineoplastic Agents - chemistry ; Antioxidants ; Apoptosis - drug effects ; Binding ; Biochemistry ; Biomedical and Life Sciences ; Biomedical research ; Cell Biology ; Cell Line, Tumor ; Coordination Complexes - administration & dosage ; Coordination Complexes - chemistry ; Copper ; Copper - administration & dosage ; Copper - chemistry ; Cytotoxicity ; DNA - chemistry ; Fibroblasts - drug effects ; Flavanones - administration & dosage ; Flavanones - chemistry ; Hesperidin - administration & dosage ; Hesperidin - chemistry ; Human ; Human Umbilical Vein Endothelial Cells - drug effects ; Humans ; Life Sciences ; Ligands ; Lung cancer ; Lung Neoplasms - chemistry ; Lung Neoplasms - drug therapy ; Lungs ; Medicine/Public Health ; Microbiology ; Pharmacology/Toxicology ; Plant Physiology ; Reduction ; Serum albumin ; Tumors ; Veins
Is Part Of: Biometals, 2016-02, Vol.29 (1), p.39-52
Description: Copper(II) complexes [Cu(H 2 O) 2 (L1)(phen)](ClO 4 ) ( 1 ) and [Cu(H 2 O)(L2)(phen)](ClO 4 ) ( 2 ) (HL1 = naringenin; HL2 = hesperetin) were obtained, in which an anionic flavonoid ligand is attached to the metal center along with 1,10-phenanthroline (phen) as co-ligand. Complexes ( 1 ) and ( 2 ) were assayed for their cytotoxic activity against A549 lung carcinoma and against normal lung fibroblasts (LL-24) and human umbilical vein endothelial cells (HUVEC). We found IC 50 = 16.42 µM ( 1 ) and IC 50 = 5.82 µM ( 2 ) against A549 tumor cells. Complexes ( 1 ) and ( 2 ) exhibited slight specificity, being more cytotoxic against malignant than against non-malignant cells. 1 and 2 induced apoptosis on A549 cells in a mitochondria-independent pathway, and showed antioxidant activity. The antioxidant effect of the complexes could possibly improve their apoptotic action, most likely by a PI3K-independent reduction of autophagy. Complexes ( 1 ) and ( 2 ) interact in vitro with calf thymus DNA by an intercalative binding mode. EPR data indicated that 1 and 2 interact with human serum albumin (HSA) forming mixed ligand species. Graphical abstract
Publisher: Dordrecht: Springer Netherlands
Language: English;Dutch
Identifier: ISSN: 0966-0844
EISSN: 1572-8773
DOI: 10.1007/s10534-015-9894-0
PMID: 26582127
Source: MEDLINE
ProQuest Central

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Copper(II) complexes with naringenin and hesperetin: cytotoxic activity against A 549 human lung adenocarcinoma cells and investigation on the mode of action

Springer Science+Business Media New York 2015 ;Springer Science+Business Media New York 2016 ;ISSN: 0966-0844 ;EISSN: 1572-8773 ;DOI: 10.1007/s10534-015-9894-0 ;PMID: 26582127

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