Ngôn ngữ:

Physiological Risk Factors for Severe High-Altitude Illness: A Prospective Cohort Study

American journal of respiratory and critical care medicine, 2012-01, Vol.185 (2), p.192-198 [Tạp chí có phản biện]

2015 INIST-CNRS ;Copyright American Thoracic Society Jan 15, 2012 ;ISSN: 1073-449X ;EISSN: 1535-4970 ;DOI: 10.1164/rccm.201108-1396OC ;PMID: 22071330

Tài liệu số/Tài liệu điện tử

Trích dẫn Trích dẫn bởi

Gửi đến

Nhan đề:
Physiological Risk Factors for Severe High-Altitude Illness: A Prospective Cohort Study
Tác giả: RICHALET, Jean-Paul ; LARMIGNAT, Philippe ; POITRINE, Eric ; LETOURNEL, Murielle ; CANOUÏ-POITRINE, Florence
Chủ đề: Acetazolamide - administration & dosage ; Acute Disease ; Adult ; Altitude Sickness - complications ; Altitude Sickness - epidemiology ; Altitude Sickness - etiology ; Altitude Sickness - physiopathology ; Altitude Sickness - prevention & control ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood and lymphatic vessels ; Brain Edema - epidemiology ; Brain Edema - etiology ; Brain Edema - physiopathology ; Brain Edema - prevention & control ; Cardiology. Vascular system ; Cohort Studies ; Confidence Intervals ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Diuretics - administration & dosage ; Exercise Test ; Female ; France - epidemiology ; Headache - etiology ; Humans ; Hypertension, Pulmonary - epidemiology ; Hypertension, Pulmonary - etiology ; Hypertension, Pulmonary - physiopathology ; Hypertension, Pulmonary - prevention & control ; Intensive care medicine ; Male ; Medical sciences ; Middle Aged ; Odds Ratio ; Prospective Studies ; Risk Assessment ; Risk Factors ; Severity of Illness Index
Là 1 phần của: American journal of respiratory and critical care medicine, 2012-01, Vol.185 (2), p.192-198
Mô tả: An increasing number of persons, exposed to high altitude for leisure, sport, or work, may suffer from severe high-altitude illness. To assess, in a large cohort of subjects, the association between physiological parameters and the risk of altitude illness and their discrimination ability in a risk prediction model. A total of 1,326 persons went through a hypoxic exercise test before a sojourn above 4,000 m. They were then monitored up at high altitude and classified as suffering from severe high-altitude illness (SHAI) or not. Analysis was stratified according to acetazolamide use. Severe acute mountain sickness occurred in 314 (23.7%), high-altitude pulmonary edema in 22 (1.7%), and high-altitude cerebral edema in 13 (0.98%) patients. Among nonacetazolamide users (n = 917), main factors independently associated with SHAI were previous history of SHAI (adjusted odds ratios [aOR], 12.82; 95% confidence interval [CI], 6.95-23.66; P < 0.001), ascent greater than 400 m/day (aOR, 5.89; 95% CI, 3.78-9.16; P < 0.001), history of migraine (aOR, 2.28; 95% CI, 1.28-4.07; P = 0.005), ventilatory response to hypoxia at exercise less than 0.78 L/minute/kg (aOR, 6.68; 95% CI, 3.83-11.63; P < 0.001), and desaturation at exercise in hypoxia equal to or greater than 22% (aOR, 2.50; 95% CI, 1.52-4.11; P < 0.001). The last two parameters improved substantially the discrimination ability of the multivariate prediction model (C-statistic rose from 0.81 to 0.88; P < 0.001). Preventive use of acetazolamide reduced the relative risk of SHAI by 44%. In a large population of altitude visitors, chemosensitivity parameters (high desaturation and low ventilatory response to hypoxia at exercise) were independent predictors of severe high-altitude illness. They improved the discrimination ability of a risk prediction model.
Nơi xuất bản: New York, NY: American Thoracic Society
Ngôn ngữ: English
Số nhận dạng: ISSN: 1073-449X
EISSN: 1535-4970
DOI: 10.1164/rccm.201108-1396OC
PMID: 22071330
Nguồn: GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection
ProQuest Central

Trở lại danh sách kết quả

Kết quả 1 Tiếp theo Tới trang tiếp theo


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Physiological Risk Factors for Severe High-Altitude Illness: A Prospective Cohort Study

2015 INIST-CNRS ;Copyright American Thoracic Society Jan 15, 2012 ;ISSN: 1073-449X ;EISSN: 1535-4970 ;DOI: 10.1164/rccm.201108-1396OC ;PMID: 22071330

Đang tìm Cơ sở dữ liệu bên ngoài...