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Malaria, COVID-19 and angiotensin-converting enzyme 2: what does the available population data say?

Open biology, 2021-10, Vol.11 (10), p.210213-210213 [Peer Reviewed Journal]

2021 The Authors. 2021 ;ISSN: 2046-2441 ;EISSN: 2046-2441 ;DOI: 10.1098/rsob.210213 ;PMID: 34637655

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  • Title:
    Malaria, COVID-19 and angiotensin-converting enzyme 2: what does the available population data say?
  • Author: De, A ; Dash, M ; Tiwari, A ; Sinha, A
  • Subjects: ACE2 ; Alleles ; Angiotensin-Converting Enzyme 2 - genetics ; COVID-19 ; COVID-19 - complications ; COVID-19 - epidemiology ; Genetic Predisposition to Disease ; Genetic Variation ; Geography ; Global Health ; Humans ; India ; malaria ; Malaria - complications ; Malaria - epidemiology ; Mutation ; Open Questions
  • Is Part Of: Open biology, 2021-10, Vol.11 (10), p.210213-210213
  • Description: The etiopathogenesis of COVID-19 and its differential geographic spread suggest some populations are apparently 'less affected' through many host-related factors that involve angiotensin-converting enzyme 2 (ACE2) protein, which is also the entry receptor for SARS-CoV-2. The role of ACE2 has been well studied in COVID-19 but not in the context of malaria and COVID-19. We have previously suggested how malaria might intersect with COVID-19 through mutation and here we evaluate the currently available data that could provide a link between the two diseases. Based on the existing global and Indian data on malaria, COVID-19 and the suggested mutation, the association could not be examined robustly, neither accepting nor refuting the suggested hypothesis. We strongly recommend targeted evaluation of this hypothesis through carefully designed robust molecular epidemiological studies.
  • Publisher: England: The Royal Society
  • Language: English
  • Identifier: ISSN: 2046-2441
    EISSN: 2046-2441
    DOI: 10.1098/rsob.210213
    PMID: 34637655
  • Source: GFMER Free Medical Journals
    MEDLINE
    PubMed Central
    ROAD: Directory of Open Access Scholarly Resources
    DOAJ Directory of Open Access Journals
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