Language:

Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding

Proceedings of the National Academy of Sciences - PNAS, 2012-12, Vol.109 (50), p.20714-20719 [Peer Reviewed Journal]

copyright © 1993-2008 National Academy of Sciences of the United States of America ;Copyright National Academy of Sciences Dec 11, 2012 ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.1208342109 ;PMID: 23185000

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding
Author: Gourley, Shannon L. ; Swanson, Andrew M. ; Jacobs, Andrea M. ; Howell, Jessica L. ; Mo, Michelle ; DiLeone, Ralph J. ; Koleske, Anthony J. ; Taylor, Jane R.
Subjects: Affect - drug effects ; Affect - physiology ; Amitriptyline - pharmacology ; Animals ; Antidepressants ; Antidepressive Agents, Tricyclic - pharmacology ; Behavior, Animal - drug effects ; Behavior, Animal - physiology ; Behavioral neuroscience ; Biological Sciences ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - antagonists & inhibitors ; Brain-Derived Neurotrophic Factor - genetics ; Brain-Derived Neurotrophic Factor - physiology ; Conditioning (Psychology) - drug effects ; Conditioning (Psychology) - physiology ; Corticosterone ; Corticosterone - pharmacology ; Corticosterone - physiology ; Cortisone ; Decision making ; Dendritic spines ; Dendritic Spines - drug effects ; Dendritic Spines - physiology ; Depressive disorders ; Emotional disorders ; Gene Knockdown Techniques ; Glucocorticoid receptors ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mifepristone - pharmacology ; Motivation ; Motivation - drug effects ; Motivation - physiology ; Prefrontal Cortex - drug effects ; Prefrontal Cortex - physiology ; Rats ; Rats, Sprague-Dawley ; Receptors, Glucocorticoid - antagonists & inhibitors ; Receptors, Glucocorticoid - physiology ; Rodents ; Stress ; Stress, Physiological
Is Part Of: Proceedings of the National Academy of Sciences - PNAS, 2012-12, Vol.109 (50), p.20714-20719
Description: Stressor exposure biases decision-making strategies from those based on the relationship between actions and their consequences to others restricted by stimulus-response associations. Chronic Stressor exposure also desensitizes glucocorticoid receptors (GR) and diminishes motivation to acquire food reinforcement although causal relationships are largely not established. We show that a history of chronic exposure to the GR ligand corticosterone or acute posttraining GR blockade with RU38486 makes rodents less able to perform actions based on their consequences. Thus, optimal GR binding is necessary for the consolidation of new response-outcome learning. In contrast medial prefrontal (but not striatal) BDNF can account for stress-related amotivation, in that selective medial prefrontal cortical Bdnf knockdown decreases break-point ratios in a progressive-ratio task. Knockdown also increases vulnerability to RU38486. Despite the role of BDNF in dendritic spine reorganization, deep-layer spine remodeling does not obviously parallel progressive-ratio response patterns, but treatment with the Na⁺-channel inhibitor riluzole reverses corticosteroid-induced motivational deficits and restores prefrontal BDNF expression after corticosterone. We argue that when prefrontal neurotrophin systems are compromised, and GR-mediated hypothalamic-pituitary-adrenal axis feedback is desensitized (as in the case of chronic stress hormone exposure), amotivation and inflexible maladaptive response strategies that contribute to stressrelated mood disorders result.
Publisher: United States: National Academy of Sciences
Language: English
Identifier: ISSN: 0027-8424
EISSN: 1091-6490
DOI: 10.1073/pnas.1208342109
PMID: 23185000
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding

copyright © 1993-2008 National Academy of Sciences of the United States of America ;Copyright National Academy of Sciences Dec 11, 2012 ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.1208342109 ;PMID: 23185000

Searching Remote Databases, Please Wait