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The effect of activated platelet-rich plasma (PRP) on tricalcium hydroxyapatite phosphate healing in experimental, partial defects of long bone shafts in animal models

Polish journal of veterinary sciences, 2019-06, Vol.22 (2), p.243-243 [Peer Reviewed Journal]

Copyright© by the Polish Academy of Sciences. ;Copyright Polish Academy of Sciences, Committee of Veterinary Sciences 2019 ;ISSN: 1505-1773 ;EISSN: 2300-2557 ;DOI: 10.24425/pjvs.2019.127092 ;PMID: 31269346

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Title:
The effect of activated platelet-rich plasma (PRP) on tricalcium hydroxyapatite phosphate healing in experimental, partial defects of long bone shafts in animal models
Author: Skwarcz, S ; Bryzek, I ; Gregosiewicz, A ; Warda, E ; Gawęda, K ; Tarczyńska, M ; Skwarcz, J ; Nadulski, R ; Starek, A ; Sanford, J
Subjects: Animal models ; Animals ; Bone (long) ; Bone and Bones - injuries ; Bone density ; Bone healing ; Bone imaging ; Bone Regeneration - drug effects ; Bone Substitutes - administration & dosage ; Bone Substitutes - pharmacology ; Bones ; Calcium phosphates ; Calcium Phosphates - administration & dosage ; Calcium Phosphates - pharmacology ; Clinical medicine ; Computed tomography ; Cytokines ; Defects ; Dentistry ; Durapatite - administration & dosage ; Durapatite - pharmacology ; Excavation ; Experiments ; Femur ; Growth factors ; Healing ; Hydroxyapatite ; Male ; Medical research ; Orthopedics ; Physiology ; Plasma ; Platelet-Rich Plasma ; Platelets ; Rabbits ; Radiology ; Skin & tissue grafts ; Substitute bone ; Tissue engineering ; Tissue Scaffolds ; Tricalcium phosphate ; Veterinary medicine ; Wound Healing - drug effects
Is Part Of: Polish journal of veterinary sciences, 2019-06, Vol.22 (2), p.243-243
Description: The purpose of the study was to assess the effect of autologous activated platelet-rich plasma on healing of a bone substitute - tricalcium phosphate hydroxyapatite in experimental long bone defects using an animal model. The experiment involved an animal model of femoral defect. 24 Termond white rabbits were used in the study. We evaluated the effect of autologous platelet-rich plasma on tricalcium phosphate using classical radiology, micro-CT studies, strength tests and histological evaluation. Radiological and histological assessment did not show a beneficial effect of PRP together with a bone substitute in comparison to filling the defects only with bone replacement material. The only benefit of adding platelet-rich plasma to a bone substitute was shown in microCT imaging. Autologous, activated platelet-rich plasma combined with hydroxyapatite tricalcium phosphate has a positive effect on the remodeling of the newly formed bone tissue, increasing its density.
Publisher: Germany: Polish Academy of Sciences, Committee of Veterinary Sciences
Language: English;Polish
Identifier: ISSN: 1505-1773
EISSN: 2300-2557
DOI: 10.24425/pjvs.2019.127092
PMID: 31269346
Source: MEDLINE
ProQuest Central

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The effect of activated platelet-rich plasma (PRP) on tricalcium hydroxyapatite phosphate healing in experimental, partial defects of long bone shafts in animal models

Copyright© by the Polish Academy of Sciences. ;Copyright Polish Academy of Sciences, Committee of Veterinary Sciences 2019 ;ISSN: 1505-1773 ;EISSN: 2300-2557 ;DOI: 10.24425/pjvs.2019.127092 ;PMID: 31269346

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