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CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of [beta]-catenin pathway

Journal of experimental & clinical cancer research, 2018-11, Vol.37 (1) [Peer Reviewed Journal]

COPYRIGHT 2018 BioMed Central Ltd. ;COPYRIGHT 2018 BioMed Central Ltd. ;ISSN: 0392-9078 ;EISSN: 1756-9966 ;DOI: 10.1186/s13046-018-0936-7

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  • Title:
    CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of [beta]-catenin pathway
  • Author: Bi, Wen ; Huang, Jiayu ; Nie, Chunlei ; Liu, Bo ; He, Guoqing ; Han, Jihua ; Pang, Rui ; Ding, Zhaoming ; Xu, Jin ; Zhang, Jiewu
  • Is Part Of: Journal of experimental & clinical cancer research, 2018-11, Vol.37 (1)
  • Description: Background As a type of recently discovered noncoding RNA, circular RNAs (circRNAs) exert pivot biological functions in diverse cancers. However, the role of circRNA_102171 in papillary thyroid cancer (PTC) has not been investigated. Our study was focused on the functional investigation toward circRNA_102171 in PTC progression. And we also aimed to reveal its potential molecular mechanism. Methods The expression pattern of circRNA_102171 was determined using quantitative polymerase chain reaction (qPCR) in PTC samples and cell lines. Cell proliferation was examined utilizing CCK8, colony formation and EdU incorporation assays. Apoptosis was analyzed by Annexin V/PI staining and FACS detection. Cell migration and invasion was measured using Transwell assay. Tumor growth in vivo was determined through a xenograft assay. RNA-pulldown, RNA-IP (RIP) and RNA-EMSA were used to analyze the interaction between circRNA_102171 and CTNNBIP1. Results CircRNA_102171 expression was upregulated in tumor tissues and cell lines. CircRNA_102171 silencing suppressed PTC cell proliferation, migration and invasion while promoting apoptosis. CircRNA_102171 knockdown inhibited PTC growth in vivo. CircRNA_102171 interacted with CTNNBIP1 to block its interaction with the [beta]-catenin/TCF3/TCF4/LEF1 complex, leading to activation of Wnt/[beta]-catenin pathway. Conclusions CircRNA_102171 overexpression promotes PTC progression through activating Wnt/[beta]-catenin pathway in a CTNNBIP1-dependent way. Keywords: Papillary thyroid cancer, Circular RNA, circRNA_102171, CTNNBIP1, Wnt/[beta]-catenin
  • Publisher: BioMed Central Ltd
  • Language: English
  • Identifier: ISSN: 0392-9078
    EISSN: 1756-9966
    DOI: 10.1186/s13046-018-0936-7
  • Source: PubMed Central
    Springer Nature OA/Free Journals
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    ProQuest Central
    DOAJ Directory of Open Access Journals
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