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SARS‐CoV‐2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells

The EMBO journal, 2020-05, Vol.39 (10) [Peer Reviewed Journal]

2020 The Authors. Published under the terms of the CC BY 4.0 license ;ISSN: 0261-4189 ;EISSN: 1460-2075 ;DOI: 10.15252/embj.20105114 ;PMID: 32246845

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  • Title:
    SARS‐CoV‐2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells
  • Author: Lukassen, Soeren ; Chua, Robert Lorenz ; Trefzer, Timo ; Kahn, Nicolas C ; Schneider, Marc A ; Muley, Thomas ; Winter, Hauke ; Meister, Michael ; Veith, Carmen ; Boots, Agnes W ; Hennig, Bianca P ; Kreuter, Michael ; Conrad, Christian ; Eils, Roland
  • Subjects: Resource
  • Is Part Of: The EMBO journal, 2020-05, Vol.39 (10)
  • Description: The SARS ‐CoV‐2 pandemic affecting the human respiratory system severely challenges public health and urgently demands for increasing our understanding of COVID ‐19 pathogenesis, especially host factors facilitating virus infection and replication. SARS ‐CoV‐2 was reported to enter cells via binding to ACE 2, followed by its priming by TMPRSS 2. Here, we investigate ACE 2 and TMPRSS 2 expression levels and their distribution across cell types in lung tissue (twelve donors, 39,778 cells) and in cells derived from subsegmental bronchial branches (four donors, 17,521 cells) by single nuclei and single cell RNA sequencing, respectively. While TMPRSS 2 is strongly expressed in both tissues, in the subsegmental bronchial branches ACE 2 is predominantly expressed in a transient secretory cell type. Interestingly, these transiently differentiating cells show an enrichment for pathways related to RHO GTP ase function and viral processes suggesting increased vulnerability for SARS ‐CoV‐2 infection. Our data provide a rich resource for future investigations of COVID ‐19 infection and pathogenesis. A single‐cell RNA ‐seq resource identifies expression of coronavirus entry‐linked host cofactors ACE 2 , TMPRSS 2 and FURIN primarily in bronchial cells in cells transitioning from secretory to ciliated identity.
  • Publisher: Hoboken: John Wiley and Sons Inc
  • Language: English
  • Identifier: ISSN: 0261-4189
    EISSN: 1460-2075
    DOI: 10.15252/embj.20105114
    PMID: 32246845
  • Source: GFMER Free Medical Journals
    PubMed Central
    Alma/SFX Local Collection
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