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Targeting Strategies for Tissue-Specific Drug Delivery

Cell, 2020-04, Vol.181 (1), p.151-167 [Peer Reviewed Journal]

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Title:
Targeting Strategies for Tissue-Specific Drug Delivery
Author: Zhao, Zongmin ; Ukidve, Anvay ; Kim, Jayoung ; Mitragotri, Samir
Is Part Of: Cell, 2020-04, Vol.181 (1), p.151-167
Description: Off-target effects of systemically administered drugs have been a major hurdle in designing therapies with desired efficacy and acceptable toxicity. Developing targeting strategies to enable site-specific drug delivery holds promise in reducing off-target effects, decreasing unwanted toxicities, and thereby enhancing a drug’s therapeutic efficacy. Over the past three decades, a large body of literature has focused on understanding the biological barriers that hinder tissue-specific drug delivery and strategies to overcome them. These efforts have led to several targeting strategies that modulate drug delivery in both the preclinical and clinical settings, including small molecule-, nucleic acid-, peptide-, antibody-, and cell-based strategies. Here, we discuss key advances and emerging concepts for tissue-specific drug delivery approaches and their clinical translation. Zhao et al. review the different strategies to target drugs to specific tissues, giving critical insight into what has worked, what has not, and what seems promising.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0092-8674
EISSN: 1097-4172
DOI: 10.1016/j.cell.2020.02.001
PMID: 32243788
Source: Cell Press Free Archives

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