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Cardiovascular risk of smoking and benefits of smoking cessation

Journal of thoracic disease, 2020-07, Vol.12 (7), p.3866-3876

2020 Journal of Thoracic Disease. All rights reserved. 2020 Journal of Thoracic Disease. ;ISSN: 2072-1439 ;EISSN: 2077-6624 ;DOI: 10.21037/jtd.2020.02.47 ;PMID: 32802468

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  • Title:
    Cardiovascular risk of smoking and benefits of smoking cessation
  • Author: Gallucci, Giuseppina ; Tartarone, Alfredo ; Lerose, Rosa ; Lalinga, Anna Vittoria ; Capobianco, Alba Maria
  • Subjects: Review on Improving Outcomes in Lung Cancer Through Early Diagnosis and Smoking Cessation
  • Is Part Of: Journal of thoracic disease, 2020-07, Vol.12 (7), p.3866-3876
  • Description: Smoking increases mortality from all causes and has a crucial role in atherosclerotic cardiovascular disease (ASCVD). Active smoking and secondhand smoke exposure determine more than 30% of coronary heart disease (CHD) mortality. The exact mechanisms of cardiovascular damages are not well known, but the detrimental effect of smoking on endothelial function has long been recognized. Smoking elicits oxidative processes, negatively affects platelet function, fibrinolysis, inflammation and vasomotor function; all these proatherogenic effects double the 10-year risk of fatal events in smokers compared to non smokers. An intriguing issue about smoking is the vulnerability of female gender. The mortality from cardiovascular diseases (CVDs) is higher in female than male smokers and female smokers show a 25% higher risk of developing CHD than men with the same exposure to tobacco smoke. This female vulnerability seems to be related to genes involved in thrombin signaling. The effects of smoking cessation have also been extensively studied. Cessation at an early age (40 years) has an impressive 90% reduction in the excess risk of death. In this review we report recent data about the causal link between smoking and CVDs and about the benefits of smoking cessation.
  • Publisher: AME Publishing Company
  • Language: English
  • Identifier: ISSN: 2072-1439
    EISSN: 2077-6624
    DOI: 10.21037/jtd.2020.02.47
    PMID: 32802468
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    PubMed Central
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