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Ion mobility-based sterolomics reveals spatially and temporally distinctive sterol lipids in the mouse brain

Nature communications, 2021-07, Vol.12 (1), p.4343-4343, Article 4343 [Peer Reviewed Journal]

2021. The Author(s). ;The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2021 ;ISSN: 2041-1723 ;EISSN: 2041-1723 ;DOI: 10.1038/s41467-021-24672-x ;PMID: 34267224

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Title:
Ion mobility-based sterolomics reveals spatially and temporally distinctive sterol lipids in the mouse brain
Author: Li, Tongzhou ; Yin, Yandong ; Zhou, Zhiwei ; Qiu, Jiaqian ; Liu, Wenbin ; Zhang, Xueting ; He, Kaiwen ; Cai, Yuping ; Zhu, Zheng-Jiang
Subjects: Age ; Aging ; Aging - physiology ; Animals ; Brain ; Brain - metabolism ; Brain Chemistry ; Female ; Ionic mobility ; Ions ; Isomerism ; Learning algorithms ; Libraries ; Lipid metabolism ; Lipidomics - methods ; Lipids ; Lipids - analysis ; Lipids - chemistry ; Machine Learning ; Mass spectrometry ; Mass spectroscopy ; Metabolism ; Mice ; Mice, Inbred C57BL ; Mobility ; Neurodegenerative diseases ; Scientific imaging ; Spatial analysis ; Spectroscopy ; Sterols ; Sterols - analysis ; Sterols - chemistry ; Sterols - metabolism ; Tandem Mass Spectrometry - methods ; Technology
Is Part Of: Nature communications, 2021-07, Vol.12 (1), p.4343-4343, Article 4343
Description: Aberrant sterol lipid metabolism is associated with physiological dysfunctions in the aging brain and aging-dependent disorders such as neurodegenerative diseases. There is an unmet demand to comprehensively profile sterol lipids spatially and temporally in different brain regions during aging. Here, we develop an ion mobility-mass spectrometry based four-dimensional sterolomics technology leveraged by a machine learning-empowered high-coverage library (>2000 sterol lipids) for accurate identification. We apply this four-dimensional technology to profile the spatially resolved landscapes of sterol lipids in ten functional regions of the mouse brain, and quantitatively uncover ~200 sterol lipids uniquely distributed in specific regions with concentrations spanning up to 8 orders of magnitude. Further spatial analysis pinpoints age-associated differences in region-specific sterol lipid metabolism, revealing changes in the numbers of altered sterol lipids, concentration variations, and age-dependent coregulation networks. These findings will contribute to our understanding of abnormal sterol lipid metabolism and its role in brain diseases.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 2041-1723
EISSN: 2041-1723
DOI: 10.1038/s41467-021-24672-x
PMID: 34267224
Source: Open Access: DOAJ Directory of Open Access Journals
Open Access: PubMed Central
AUTh Library subscriptions: ProQuest Central
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Ion mobility-based sterolomics reveals spatially and temporally distinctive sterol lipids in the mouse brain

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