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Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity

Marine drugs, 2018-10, Vol.16 (11), p.410 [Peer Reviewed Journal]

2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2018 by the authors. 2018 ;ISSN: 1660-3397 ;EISSN: 1660-3397 ;DOI: 10.3390/md16110410 ;PMID: 30373208

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Title:
Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity
Author: Rocha, Djenisa H A ; Seca, Ana M L ; Pinto, Diana C G A
Subjects: Algae ; Animals ; Anticancer properties ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - isolation & purification ; Antineoplastic Agents - metabolism ; Antineoplastic Agents - pharmacology ; Antitumor activity ; Antitumor agents ; Biocompatibility ; Biological Factors - chemistry ; Biological Factors - isolation & purification ; Biological Factors - metabolism ; Biological Factors - pharmacology ; bromophenols ; Cancer ; Cancer therapies ; Carotenoids ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Chemotherapy ; cholest-5-en-3β,7α-diol ; Colorectal cancer ; cytotoxic activity ; Cytotoxicity ; dictyolactone ; Drugs ; halomon ; Humans ; In vivo methods and tests ; Inhibitory Concentration 50 ; laurebiphenyl ; Lung cancer ; Metabolites ; Mode of action ; Neoplasms - drug therapy ; Polyphenols ; Prostate ; Review ; Seaweed - metabolism ; Seaweeds ; Secondary metabolites ; Selectivity ; Sterols ; Sterols - chemistry ; Sterols - isolation & purification ; Sterols - metabolism ; Sterols - pharmacology ; Structure-Activity Relationship ; Terpenes ; Terpenes - chemistry ; Terpenes - isolation & purification ; Terpenes - metabolism ; Terpenes - pharmacology ; terpenoids ; Toxicity ; Xenograft Model Antitumor Assays
Is Part Of: Marine drugs, 2018-10, Vol.16 (11), p.410
Description: Isolation, finding or discovery of novel anticancer agents is very important for cancer treatment, and seaweeds are one of the largest producers of chemically active metabolites with valuable cytotoxic properties, and therefore can be used as new chemotherapeutic agents or source of inspiration to develop new ones. Identification of the more potent and selective anticancer components isolated from brown, green and red seaweeds, as well as studies of their mode of action is very attractive and constitute a small but relevant progress for pharmacological applications. Several researchers have carried out in vitro and in vivo studies in various cell lines and have disclosed the active metabolites among the terpenoids, including carotenoids, polyphenols and alkaloids that can be found in seaweeds. In this review the type of metabolites and their cytotoxic or antiproliferative effects will be discussed additionally their mode of action, structure-activity relationship and selectivity will also be revealed. The diterpene dictyolactone, the sterol cholest-5-en-3β,7α-diol and the halogenated monoterpene halomon are among the reported compounds, the ones that present sub-micromolar cytotoxicity. Additionally, one dimeric sesquiterpene of the cyclolaurane-type, three bromophenols and one halogenated monoterpene should be emphasized because they exhibit half maximal inhibitory concentration (IC ) values between 1⁻5 µM against several cell lines.
Publisher: Switzerland: MDPI AG
Language: English
Identifier: ISSN: 1660-3397
EISSN: 1660-3397
DOI: 10.3390/md16110410
PMID: 30373208
Source: Geneva Foundation Free Medical Journals at publisher websites
AUTh Library subscriptions: ProQuest Central
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Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity

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