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Sterols in spermatogenesis and sperm maturation

Journal of lipid research, 2013-01, Vol.54 (1), p.20-33 [Peer Reviewed Journal]

2013 © 2013 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. ;Copyright © 2013 by the American Society for Biochemistry and Molecular Biology, Inc. 2013 ;ISSN: 0022-2275 ;EISSN: 1539-7262 ;DOI: 10.1194/jlr.R032326 ;PMID: 23093550

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  • Title:
    Sterols in spermatogenesis and sperm maturation
  • Author: Keber, Rok ; Rozman, Damjana ; Horvat, Simon
  • Subjects: Animals ; cholesterol ; cytochrome P450 ; Gene Expression Regulation, Developmental ; Humans ; Male ; male germ cells ; neutral sterols ; Reproduction ; Review ; sperm development ; Sperm Maturation ; Spermatozoa - cytology ; Spermatozoa - metabolism ; sterol intermediates ; Sterols - biosynthesis ; Sterols - metabolism ; sterols in reproduction ; Testis - cytology ; Testis - enzymology ; Testis - metabolism ; Testis - physiology ; testis-specific gene expression
  • Is Part Of: Journal of lipid research, 2013-01, Vol.54 (1), p.20-33
  • Description: Mammalian spermatogenesis is a complex developmental program in which a diploid progenitor germ cell transforms into highly specialized spermatozoa. One intriguing aspect of sperm production is the dynamic change in membrane lipid composition that occurs throughout spermatogenesis. Cholesterol content, as well as its intermediates, differs vastly between the male reproductive system and nongonadal tissues. Accumulation of cholesterol precursors such as testis meiosis-activating sterol and desmosterol is observed in testes and spermatozoa from several mammalian species. Moreover, cholesterogenic genes, especially meiosis-activating sterol-producing enzyme cytochrome P450 lanosterol 14α-demethylase, display stage-specific expression patterns during spermatogenesis. Discrepancies in gene expression patterns suggest a complex temporal and cell-type specific regulation of sterol compounds during spermatogenesis, which also involves dynamic interactions between germ and Sertoli cells. The functional importance of sterol compounds in sperm production is further supported by the modulation of sterol composition in spermatozoal membranes during epididymal transit and in the female reproductive tract, which is a prerequisite for successful fertilization. However, the exact role of sterols in male reproduction is unknown. This review discusses sterol dynamics in sperm maturation and describes recent methodological advances that will help to illuminate the complexity of sperm formation and function.
  • Publisher: United States: Elsevier Inc
  • Language: English
  • Identifier: ISSN: 0022-2275
    EISSN: 1539-7262
    DOI: 10.1194/jlr.R032326
    PMID: 23093550
  • Source: DOAJ Directory of Open Access Journals
    GFMER Free Medical Journals
    MEDLINE
    PubMed Central
    Alma/SFX Local Collection
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