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Appraisal of patient-level health economic models of severe mental illness: systematic review

British journal of psychiatry, 2022-02, Vol.220 (2), p.86-97 [Peer Reviewed Journal]

Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists ;Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Royal College of Psychiatrists. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 0007-1250 ;EISSN: 1472-1465 ;DOI: 10.1192/bjp.2021.121 ;PMID: 35049466

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Title:
Appraisal of patient-level health economic models of severe mental illness: systematic review
Author: Altunkaya, James ; Lee, Jung-Seok ; Tsiachristas, Apostolos ; Waite, Felicity ; Freeman, Daniel ; Leal, José
Subjects: Abstracts ; Academic Psychiatry ; Appraisal ; Appropriateness ; Bipolar disorder ; Check lists ; Checklists ; Chronic illnesses ; Clinical outcomes ; Clinical research ; Clinical trials ; Coronaviruses ; Cost analysis ; COVID-19 ; Decision makers ; Depressive personality disorders ; Economic models ; Extraction ; Extrapolation ; Health care ; Intervention ; Life expectancy ; Mental depression ; Mental disorders ; Mental health care ; Mental health services ; Modelling ; Monte Carlo simulation ; Mortality ; Parameters ; Patients ; Psychoses ; Psychosis ; Quality control ; Review ; Schizophrenia ; Simulation ; Systematic review ; Verification
Is Part Of: British journal of psychiatry, 2022-02, Vol.220 (2), p.86-97
Description: Healthcare decision makers require accurate long-term economic models to evaluate the cost-effectiveness of new mental health interventions. To assess the suitability of current patient-level economic models to estimate long-term economic outcomes in severe mental illness. We undertook pre-specified systematic searches in MEDLINE, Embase and PsycINFO to identify reviews and stand-alone publications of economic models of interventions for schizophrenia, bipolar disorder and major depressive disorder (PROSPERO: CRD42020158243). We screened paper titles and abstracts to identify unique patient-level economic models. We conducted a structured extraction of identified models, recording the presence of key predefined model features. Model quality and validation were appraised using the 2014 ISPOR and 2016 AdViSHE model checklists. We identified 15 unique patient-level models for psychosis and major depressive disorder from 1481 non-duplicate records. Models addressed schizophrenia (n = 6), bipolar disorder (n = 2) and major depressive disorder (n = 7). The predominant model type was discrete event simulation (n = 9). Model complexity and incorporation of patient heterogeneity varied considerably, and only five models extrapolated costs and outcomes over a lifetime horizon. Key model parameters were often based on low-quality evidence, and checklist quality assessment revealed weak model verification procedures. Existing patient-level economic models of interventions for severe mental illness have considerable limitations. New modelling efforts must be supplemented by the generation of good-quality, contemporary evidence suitable for model building. Combined effort across the research community is required to build and validate economic extrapolation models suitable for accurately assessing the long-term value of new interventions from short-term clinical trial data.
Publisher: Cambridge, UK: Cambridge University Press
Language: English
Identifier: ISSN: 0007-1250
EISSN: 1472-1465
DOI: 10.1192/bjp.2021.121
PMID: 35049466
Source: ProQuest One Psychology
Geneva Foundation Free Medical Journals at publisher websites
ProQuest Central

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Appraisal of patient-level health economic models of severe mental illness: systematic review

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