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Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes

Nature medicine, 2020-07, Vol.26 (7), p.1044-1047 [Peer Reviewed Journal]

COPYRIGHT 2020 Nature Publishing Group ;The Author(s), under exclusive licence to Springer Nature America, Inc. 2020. ;ISSN: 1078-8956 ;EISSN: 1546-170X ;DOI: 10.1038/s41591-020-0932-2 ;PMID: 32572265

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Title:
Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes
Author: Nassiri, Farshad ; Chakravarthy, Ankur ; Feng, Shengrui ; Shen, Shu Yi ; Nejad, Romina ; Zuccato, Jeffrey A ; Voisin, Mathew R ; Patil, Vikas ; Horbinski, Craig ; Aldape, Kenneth ; Zadeh, Gelareh ; De Carvalho, Daniel D
Subjects: Biomarkers, Tumor - blood ; Brain cancer ; Brain Neoplasms - blood ; Brain Neoplasms - diagnosis ; Brain Neoplasms - genetics ; Brain Neoplasms - pathology ; Brain tumors ; Cancer ; Cell-Free Nucleic Acids - blood ; CpG Islands - genetics ; Deoxyribonucleic acid ; Diagnosis ; Diagnostic systems ; DNA ; DNA methylation ; DNA Methylation - genetics ; DNA sequencing ; DNA, Neoplasm - blood ; Epigenome - genetics ; Female ; Gene Expression Regulation, Neoplastic - genetics ; Genetic aspects ; Genetic research ; Health aspects ; Humans ; Male ; Medical research ; Medicine, Experimental ; Methylation ; Neuroimaging ; Oncology, Experimental ; Surgery ; Tumors
Is Part Of: Nature medicine, 2020-07, Vol.26 (7), p.1044-1047
Description: Definitive diagnosis of intracranial tumors relies on tissue specimens obtained by invasive surgery. Noninvasive diagnostic approaches provide an opportunity to avoid surgery and mitigate unnecessary risk to patients. In the present study, we show that DNA-methylation profiles from plasma reveal highly specific signatures to detect and accurately discriminate common primary intracranial tumors that share cell-of-origin lineages and can be challenging to distinguish using standard-of-care imaging.
Publisher: United States: Nature Publishing Group
Language: English
Identifier: ISSN: 1078-8956
EISSN: 1546-170X
DOI: 10.1038/s41591-020-0932-2
PMID: 32572265
Source: AUTh Library subscriptions: ProQuest Central
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Detection and discrimination of intracranial tumors using plasma cell-free DNA methylomes

COPYRIGHT 2020 Nature Publishing Group ;The Author(s), under exclusive licence to Springer Nature America, Inc. 2020. ;ISSN: 1078-8956 ;EISSN: 1546-170X ;DOI: 10.1038/s41591-020-0932-2 ;PMID: 32572265

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