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Nanoparticle interaction with the immune system

Arhiv za higijenu rada i toksikologiju, 2015-06, Vol.66 (2), p.97-108 [Peer Reviewed Journal]

ISSN: 0004-1254 ;EISSN: 1848-6312 ;DOI: 10.1515/aiht-2015-66-2582 ;PMID: 26110471 ;CODEN: AHRTAN

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  • Title:
    Nanoparticle interaction with the immune system
  • Author: Kononenko, Veno ; Narat, Mojca ; Drobne, Damjana
  • Subjects: Antineoplastic Agents - therapeutic use ; Humans ; immune response ; Immunity, Active - drug effects ; immunomodulation ; immunotoxicity ; nanomaterials ; nanoparticle properties ; Nanoparticles - chemistry ; Nanoparticles - therapeutic use ; nanosafety ; Neoplasms - drug therapy ; Neoplasms - immunology
  • Is Part Of: Arhiv za higijenu rada i toksikologiju, 2015-06, Vol.66 (2), p.97-108
  • Description: When nanoparticles enter the body, their interactions with cells are almost unavoidable. Unintended nanoparticle interaction with immune cells may elicit a molecular response that can have toxic effects and lead to greater susceptibility to infectious diseases, autoimmune disorders, and cancer development. As evidenced by several studies, nanoparticle interactions with biological systems can stimulate inflammatory or allergic reactions and activate the complement system. Nanoparticles can also stimulate immune response by acting as adjuvants or as haptens. Immunosuppressive effects have also been reported. This article gives a brief review of in vitro and in vivo research evidencing stimulatory or suppressive effects of nanoparticles on the immune system of mammals. In order to ensure safe use of nanosized particles, future research should focus on how their physical and chemical properties influence their behaviour in the biological environment, as they not only greatly affect nanoparticle-immune system interactions but can also interfere with experimental assays.
  • Publisher: Croatia: Institute for Medical Research and Occupational Health
  • Language: English;Slovenian;Croatian
  • Identifier: ISSN: 0004-1254
    EISSN: 1848-6312
    DOI: 10.1515/aiht-2015-66-2582
    PMID: 26110471
    CODEN: AHRTAN
  • Source: Directory of Open Access Journals (DOAJ)
    AUTh Library subscriptions: ProQuest Central
    De Gruyter Journals Open Access
    MEDLINE
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