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Genome-wide association study of chronic periodontitis in a general German population

Journal of clinical periodontology, 2013-11, Vol.40 (11), p.977-985 [Peer Reviewed Journal]

2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd ;2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. ;ISSN: 0303-6979 ;EISSN: 1600-051X ;DOI: 10.1111/jcpe.12154 ;PMID: 24024966

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Title:
Genome-wide association study of chronic periodontitis in a general German population
Author: Teumer, Alexander ; Holtfreter, Birte ; Völker, Uwe ; Petersmann, Astrid ; Nauck, Matthias ; Biffar, Reiner ; Völzke, Henry ; Kroemer, Heyo K. ; Meisel, Peter ; Homuth, Georg ; Kocher, Thomas
Subjects: Adenine ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; attachment loss ; Chromosomes, Human, X - genetics ; Chronic Periodontitis - genetics ; Cohort Studies ; Cross-Sectional Studies ; Cytosine ; Dentistry ; Female ; Follow-Up Studies ; Genetic Variation - genetics ; genome-wide association studies ; Genome-Wide Association Study ; Genomics ; Genotype ; Germany ; Gum disease ; HapMap Project ; Humans ; INDEL Mutation - genetics ; Male ; Middle Aged ; Periodontal Attachment Loss - genetics ; Periodontal Pocket - genetics ; periodontitis ; Polymorphism, Single Nucleotide - genetics ; Population Surveillance ; Study of Health in Pomerania ; Thymine ; Young Adult
Is Part Of: Journal of clinical periodontology, 2013-11, Vol.40 (11), p.977-985
Description: Aim To identify loci associated with chronic periodontitis through a genome‐wide association study (GWAS). Materials and Methods A GWAS was performed in 4032 individuals of two independent cross‐sectional studies of West Pomerania (SHIP n = 3365 and SHIP‐TREND n = 667) with different periodontal case definitions. Samples were genotyped with the Affymetrix Genome‐Wide Human SNP Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genome‐based autosomal and X‐chromosomal genotypes and short insertions and deletions (INDELs) was performed in both cohorts. Finally, more than 17 million SNPs and short INDELs were analysed. Results No genome‐wide significant associations were found for any periodontitis case definition, regardless of whether individuals aged >60 years where excluded or not. Despite no single SNP association reached genome‐wide significance, the proportion of variance explained by additive effects of all common SNPs was around 23% for mean proximal attachment loss. Excluding subjects aged >60 years increased the explained variance to 34%. Conclusions No single SNPs were found to be genome‐wide significantly associated with chronic periodontitis in this study.
Publisher: United States: Blackwell Publishing Ltd
Language: English
Identifier: ISSN: 0303-6979
EISSN: 1600-051X
DOI: 10.1111/jcpe.12154
PMID: 24024966
Source: MEDLINE
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Genome-wide association study of chronic periodontitis in a general German population

2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd ;2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. ;ISSN: 0303-6979 ;EISSN: 1600-051X ;DOI: 10.1111/jcpe.12154 ;PMID: 24024966

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