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Developing a PRogram to Educate and Sensitize Caregivers to Reduce the Inappropriate Prescription Burden in the Elderly with Alzheimer's Disease

PloS one, 2024-02, Vol.19 (2), p.e0297562 [Peer Reviewed Journal]

COPYRIGHT 2024 Public Library of Science ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0297562

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  • Title:
    Developing a PRogram to Educate and Sensitize Caregivers to Reduce the Inappropriate Prescription Burden in the Elderly with Alzheimer's Disease
  • Author: Singh, Sonal ; Cocoros, Noelle M ; Li, Xiaojuan ; Mazor, Kathleen M ; Antonelli, Mary T ; Parlett, Lauren ; Paullin, Mark ; Harkins, Thomas P ; Zhou, Yunping ; Rochon, Paula A ; Platt, Richard ; Dashevsky, Inna ; Massino, Carly ; Saphirak, Cassandra ; Crawford, Sybil L ; Gurwitz, Jerry H
  • Subjects: Alzheimer's disease ; Care and treatment ; Diagnosis ; Evaluation ; Falls (Accidents) ; Prescription writing ; Prevention ; Risk factors
  • Is Part Of: PloS one, 2024-02, Vol.19 (2), p.e0297562
  • Description: Potentially inappropriate prescribing of medications in older adults, particular those with dementia, can lead to adverse drug events including falls and fractures, worsening cognitive impairment, emergency department visits, and hospitalizations. Educational mailings from health plans to patients and their providers to encourage deprescribing conversations may represent an effective, low-cost, "light touch", approach to reducing the burden of potentially inappropriate prescription use in older adults with dementia. The objective of the Developing a PRogram to Educate and Sensitize Caregivers to Reduce the Inappropriate Prescription Burden in Elderly with Alzheimer's Disease (D-PRESCRIBE-AD) trial is to evaluate the effect of a health plan based multi-faceted educational outreach intervention to community dwelling patients with dementia who are currently prescribed sedative/hypnotics, antipsychotics, or strong anticholinergics. The D-PRESCRIBE-AD is an open-label pragmatic, prospective randomized controlled trial (RCT) comparing three arms: 1) educational mailing to both the health plan patient and their prescribing physician (patient plus physician arm, n = 4814); 2) educational mailing to prescribing physician only (physician only arm, n = 4814); and 3) usual care (n = 4814) among patients with dementia enrolled in two large United States based health plans. The primary outcome is the absence of any dispensing of the targeted potentially inappropriate prescription during the 6-month study observation period after a 3-month black out period following the mailing. Secondary outcomes include dose-reduction, polypharmacy, healthcare utilization, mortality and therapeutic switching within targeted drug classes. This large pragmatic RCT will contribute to the evidence base on promoting deprescribing of potentially inappropriate medications among older adults with dementia. If successful, such light touch, inexpensive and highly scalable interventions have the potential to reduce the burden of potentially inappropriate prescribing for patients with dementia.
  • Publisher: Public Library of Science
  • Language: English
  • Identifier: ISSN: 1932-6203
    EISSN: 1932-6203
    DOI: 10.1371/journal.pone.0297562
  • Source: Public Library of Science (PLoS) Journals Open Access
    DOAJ Directory of Open Access Journals
    Geneva Foundation Free Medical Journals at publisher websites
    PubMed Central
    ProQuest Central
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