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Significant value of 18F-FDG-PET/CT in diagnosing small cervical lymph node metastases in patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy

Ai zheng, 2017-12, Vol.36 (12), p.757-766, Article 95 [Peer Reviewed Journal]

2017 The Author(s) ;COPYRIGHT 2017 BioMed Central Ltd. ;COPYRIGHT 2017 BioMed Central Ltd. ;2017. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Copyright © Wanfang Data Co. Ltd. All Rights Reserved. ;The Author(s) 2017 ;ISSN: 1000-467X ;ISSN: 2523-3548 ;ISSN: 1944-446X ;EISSN: 1944-446X ;EISSN: 2523-3548 ;DOI: 10.1186/s40880-017-0265-9 ;PMID: 29258597

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Title:
Significant value of 18F-FDG-PET/CT in diagnosing small cervical lymph node metastases in patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy
Author: Peng, Hao ; Chen, Lei ; Tang, Ling‐Long ; Li, Wen‐Fei ; Mao, Yan‐Ping ; Guo, Rui ; Zhang, Yuan ; Liu, Li‐Zhi ; Tian, Li ; Zhang, Xu ; Lin, Xiao‐Ping ; Guo, Ying ; Sun, Ying ; Ma, Jun
Subjects: 18-fluoro-2-deoxy-glucose ; 18F-PET/CT ; 18‐fluoro‐2‐deoxy‐glucose positron emission tomography with computed tomography (18F‐PET/CT) ; Cancer ; Carcinoma ; Care and treatment ; Case studies ; cervical ; Chemotherapy ; computed ; CT imaging ; Dextrose ; Diagnosis ; Disease ; emission ; Failure ; Glucose ; Hospitals ; Intensity-modulated ; Intensity-modulated radiotherapy ; lymph ; Lymphatic diseases ; Lymphatic system ; Magnetic ; Magnetic resonance image ; Magnetic resonance imaging ; Medical imaging ; Medical research ; Medicine, Experimental ; Metastasis ; Nasopharyngeal ; Nasopharyngeal cancer ; Nasopharyngeal carcinoma ; nodes ; Original ; PET imaging ; positron ; Positron emission tomography ; Radiation therapy ; Radiotherapy ; resonance ; Risk factors ; Small ; Small cervical lymph nodes ; Tomography ; with
Is Part Of: Ai zheng, 2017-12, Vol.36 (12), p.757-766, Article 95
Description: Background: Little is known about the nature of metastasis to small cervical lymph nodes (SCLNs) in the patients with nasopharyngeal carcinoma (NPC) examined by using 18-fluoro-2-deoxy-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). The present study aimed to evaluate the diagnostic values of PET/CT in identifying metastasis in SCLNs in NPC patients.Methods: Magnetic resonance images (MRI) and PET/CT scans for 470 patients with newly diagnosed, non-distant metastatic NPC were analyzed. Metastatic rates of SCLNs were defined by the positive number of SCLNs on PET/CT scans and total number of SCLNs on MRI scans. Receiver operating characteristic curve was applied to compare PET/CT-determined stage with MRI-determined stage.Results: In total, 2082 SCLNs were identified, with 808 (38.8%) ≥ 5 and < 6 mm in diameter (group A), 526 (25.3%)≥ 6 and < 7 mm in diameter (group B), 374 (18.0%) ≥ 7 and < 8 mm in diameter (group C), 237 (11.4%) ≥ 8 and < 9 mm in diameter (group D), and 137 (6.5%) ≥ 9 and < 10 mm in diameter (group E). The overall metastatic rates examined by using PET/CT for groups A, B, C, D, and E were 3.5%, 8.0%, 31.3%, 60.0%, and 83.9%, respectively (P < 0.001). In level IV/Vb, the metastatic rate for nodes ≥ 8 mm was 84.6%. PET/CT examination resulted in modification of N category and overall stage for 135 (28.7%) and 46 (9.8%) patients, respectively. The areas under curve of MRIdetermined and PET/CT-determined overall stage were 0.659 and 0.704 for predicting overall survival, 0.661 and 0.711for predicting distant metastasis-free survival, and 0.636 and 0.663 for predicting disease-free survival.Conclusions: PET/CT was more effective than MRI in identifying metastatic SCLNs, and the radiologic diagnostic criteria for metastatic lymph nodes in level IV/Vb should be re-defined.
Publisher: London: BioMed Central
Language: English;Chinese
Identifier: ISSN: 1000-467X
ISSN: 2523-3548
ISSN: 1944-446X
EISSN: 1944-446X
EISSN: 2523-3548
DOI: 10.1186/s40880-017-0265-9
PMID: 29258597
Source: AUTh Library subscriptions: ProQuest Central
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Significant value of 18F-FDG-PET/CT in diagnosing small cervical lymph node metastases in patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy

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