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Effect of Statin on Restenosis after Radius Stent Implantation in Patients with Acute Coronary Syndrome

Journal of Atherosclerosis and Thrombosis, 2005, Vol.12(6), pp.302-306

2005 Japan Atherosclerosis Society ;ISSN: 1340-3478 ;EISSN: 1880-3873 ;DOI: 10.5551/jat.12.302 ;PMID: 16394612

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Title:
Effect of Statin on Restenosis after Radius Stent Implantation in Patients with Acute Coronary Syndrome
Author: Nishikawa, Hiroaki ; Miura, Shin-ichiro ; Shimomura, Hideki ; Kawamura, Akira ; Tsujita, Kenichi ; Shirai, Kazuyuki ; Matsuo, Kunihiro ; Arai, Hidekazu ; Saku, Keijiro
Subjects: Acute coronary syndrome ; Acute Disease ; Aged ; Combined Modality Therapy ; Constriction, Pathologic - prevention & control ; Coronary Artery Disease - drug therapy ; Coronary Artery Disease - surgery ; Female ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Male ; Middle Aged ; Radius stent ; Recurrence ; Restenosis ; Statin ; Stents
Is Part Of: Journal of Atherosclerosis and Thrombosis, 2005, Vol.12(6), pp.302-306
Description: Despite reports that statin treatment reduces the rate of coronary restenosis with a balloon expandable stent, there is no evidence that statins affect the incidence of restenosis with a self-expanding Radius stent. Ninety-five patients with acute coronary syndrome who had been implanted with a Radius stent were classified into two groups: those with hyperlipidemia and initial statin treatment (statin group, n = 38) and those without statin treatment (comparative group, n = 57). At six months after stent implantation, the rate of coronary restenosis was significantly lower in the statin group (10.5%) than control group (28.1%) (p = 0.033), while there were no differences in morphology, maximal inflation presure or stent size between the two groups. Interestingly, there was no difference in the serum lipid profile between the two groups at the 6-month follow-up, although the statin group had a significantly lower rate of restenosis. In conclusion, initial statin therapy reduced the rate of coronary restenosis even when a Radius stent was implanted.
Publisher: Japan: Japan Atherosclerosis Society
Language: English
Identifier: ISSN: 1340-3478
EISSN: 1880-3873
DOI: 10.5551/jat.12.302
PMID: 16394612
Source: Geneva Foundation Free Medical Journals at publisher websites
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Effect of Statin on Restenosis after Radius Stent Implantation in Patients with Acute Coronary Syndrome

2005 Japan Atherosclerosis Society ;ISSN: 1340-3478 ;EISSN: 1880-3873 ;DOI: 10.5551/jat.12.302 ;PMID: 16394612

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