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About the role of environmental factors in carcinogenesis

E3S web of conferences, 2020-01, Vol.169, p.4003 [Peer Reviewed Journal]

ISSN: 2267-1242 ;EISSN: 2267-1242 ;DOI: 10.1051/e3sconf/202016904003

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  • Title:
    About the role of environmental factors in carcinogenesis
  • Author: Pinaev, Sergey K. ; Pinaeva, Olga G. ; Chizhov, Alexey Ya
  • Ledashcheva, T. ; Lebedev, K. ; Cherchesova, S. ; Nikol’skii, A. ; Jang, Y. ; Khaustov, A. ; Nesterov, E. ; Jashchenko, R. ; Myaskov, A. ; Chernykh, N. ; Mickevicius, S. ; Redina, M. ; Li, X. ; Bica, I. ; Lamarton, S. ; Stom, D.
  • Is Part Of: E3S web of conferences, 2020-01, Vol.169, p.4003
  • Description: There were found out the connections of the activity of the Sun and smoke of forest fires with the incidence of various forms of benign and malignant neoplasms in the population of young children 0-4 years old, in Khabarovsk Region, Russia. Thus, it was determined that so-called “sporadic” fluctuations in the incidence of neoplasms in the child population are not random. They are caused by long multi-year cycles of changes in the complex of environmental factors. The authors identified this phenomenon as “Alternative oncogenesis”, meaning by it the predominant occurrence of various forms of neoplasms in a certain period of time due to a change in the parameters of the complex of environmental factors. A proposed hypothesis is: ecologically linked oxidative stress as a cause of the epigenomic modulation leading to an imbalance between semaphorins and integrins that brings to oncogenesis.
  • Publisher: EDP Sciences
  • Language: English
  • Identifier: ISSN: 2267-1242
    EISSN: 2267-1242
    DOI: 10.1051/e3sconf/202016904003
  • Source: EDP Open
    ROAD: Directory of Open Access Scholarly Resources
    ProQuest Central
    DOAJ Directory of Open Access Journals
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