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Perspectives on long-acting growth hormone therapy in children and adults

Archives of Endocrinology and Metabolism, 2019-11, Vol.63 (6), p.601-607

This work is licensed under a Creative Commons Attribution 4.0 International License. ;ISSN: 2359-3997 ;ISSN: 2359-4292 ;EISSN: 2359-4292 ;DOI: 10.20945/2359-3997000000190 ;PMID: 31939485

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Title:
Perspectives on long-acting growth hormone therapy in children and adults
Author: Lal, Rayhan A ; Hoffman, Andrew R
Subjects: Adult ; Chemistry, Pharmaceutical ; Child ; Delayed-Action Preparations ; Drug Administration Schedule ; Drug Design ; drug development ; ENDOCRINOLOGY & METABOLISM ; Growth Disorders - drug therapy ; Growth hormone ; Human Growth Hormone - administration & dosage ; Human Growth Hormone - chemistry ; Human Growth Hormone - pharmacokinetics ; Humans ; MEDICINE, GENERAL & INTERNAL ; pharmacology ; recombinant human growth hormone ; review
Is Part Of: Archives of Endocrinology and Metabolism, 2019-11, Vol.63 (6), p.601-607
Description: Growth hormone therapy with daily injections of recombinant human growth hormone has been available since 1985, and is shown to be safe and effective treatment for short stature in children and for adult growth hormone deficiency. In an effort to produce a product that would improve patient adherence, there has been a strong effort from industry to create a long acting form of growth hormone to ease the burden of use. Technologies used to increase half-life include depot formulations, PEGylated formulations, pro-drug formulations, non-covalent albumin binding growth hormone and growth hormone fusion proteins. At present, two long acting formulations are on the market in China and South Korea, and several more promising agents are under clinical investigation at various stages of development throughout the world. Arch Endocrinol Metab. 2019;63(6):601-7.
Publisher: Brazil: Sociedade Brasileira de Endocrinologia e Metabologia
Language: English;Portuguese
Identifier: ISSN: 2359-3997
ISSN: 2359-4292
EISSN: 2359-4292
DOI: 10.20945/2359-3997000000190
PMID: 31939485
Source: SciELO
DOAJ Directory of Open Access Journals
MEDLINE

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Perspectives on long-acting growth hormone therapy in children and adults

This work is licensed under a Creative Commons Attribution 4.0 International License. ;ISSN: 2359-3997 ;ISSN: 2359-4292 ;EISSN: 2359-4292 ;DOI: 10.20945/2359-3997000000190 ;PMID: 31939485

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